Colgate Palmolive Company

University of Michigan

Katholieke Universiteit Leuven

Hans Stettler

Nico Boon

Marc Quirynen

Wim Teughels

Laurence Du-Thumm

Steven E Miller

William Giannobile

Alexander Rickard

Nielson T Baxter

Michelle Swetky

Michael Prencipe

Andre Morgan

Paul Thomson

Nihal Dogu

Turan Matur

Amy Russo

Ruth Hinrichs

Gitte Loozen

Andre Michelle Morgan

The present disclosure relates to methods for characterizing and diagnosing dental diseases. In particular, the present disclosure relates to methods for characterizing and diagnosing dental disease (e.g., gingivitis and periodontal disease) based on levels of AI-2 in oral fluids and plaque.

Compositions and methods for characterizing and diagnosing periodontal disease

The disclosure relates to methods of enhancing beneficial oral bacteria and decreasing harmful oral bacteria comprising administering oral care compositions comprising a saccharide prebiotic, e.g., selected from D-turanose, D-melezitose, D-lactitol, myo-inositol, and N-acetyl-D-mannosamine; and oral care compositions for use in such methods. The disclosure also relates to methods of using prebiotic oral care compositions, methods of screening, and methods of manufacture.

Prebiotic oral care methods using a saccharide

This invention relates to a oral care compositions, and in particular to oral care mouthrinse compositions comprising (i) at least one source of ionic tin; and (ii) an antibacterial system comprising caprylyl glycol and 3-phenyl-1-propanol, as well as to methods of using and of making these compositions.

Oral care product and methods of use and manufacture thereof

The present invention provides an oral care composition comprising a carboxylic acid of the formula (I) wherein: Ris H, or is a substituted or unsubstituted alkyl group; and Ris H, OH, or NH; for use in: (a) selectively promoting, in an oral cavity: growth, metabolic activity or colonization of bacteria that have beneficial effects on oral health, relative to growth, metabolic activity or colonization of pathogenic oral bacteria; (b) selectively promoting, in an oral cavity, biofilm formation by bacteria that have beneficial effects on oral health, relative to biofilm formation by pathogenic oral bacteria; or (c) maintaining and/or re-establishing a healthy oral microflora. 

Prebiotic oral care compositions containing carboxylic acids

This invention relates to oral care compositions comprising a basic amino acid in free or salt from (e.g., free form arginine); zinc oxide and zinc citrate; and a fluoride source comprising stannous fluoride.

Oral care compositions and methods of use

The disclosure relates to methods of enhancing beneficial oral bacteria and decreasing harmful oral bacteria comprising administering oral care compositions comprising a saccharide prebiotic, e.g., selected from D-turanose, D-melezitose, D-lactitol, myoinositol, and N-acetyl-D-mannosamine; and oral care compositions for use in such methods. The disclosure also relates to methods of using prebiotic oral care compositions, methods of screening, and methods of manufacture.

The disclosure relates to an oral care composition an effective amount of at least one C?1-4#191 (optionally hydroxylated) alkyl glycoside, e.g., &#x3b2;-methyl-D-galactoside, wherein the glycoside promotes the growth of beneficial endogenous bacteria and negatively affects the growth of endogenous pathogenic strains of bacteria. The disclosure also relates to methods of use, methods of screening, and methods of manufacture of said oral care compositions.

Prebiotic oral care compositions containing an alkyl glycoside

The present invention provides an oral care composition comprising: (a) a dipeptide of the formula Xaa1-Xaa2 or Xaa2-Xaa1; wherein Xaa1 is an amino acid with a polar uncharged side chain; and Xaa2 is selected from an amino acid with a hydrophobic side chain, an amino acid with a polar uncharged side chain, and proline; or (b) a dipeptide of the formula Xaa3-Xaa4 or Xaa4-Xaa3; wherein Xaa3 is an amino acid with a hydrophobic side chain; and Xaa4 is selected from an amino acid with a hydrophobic side chain and an amino acid with a charged side chain.

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Hoboken, NJ, United States of America

Hans Stettler