Hoffmann-La Roche Inc.

F. Hoffmann-La Roche Ag

Hans Senn

Alfred Ross

Frank Dieterle

Goetz Schlotterbeck

G&ouml;tz Schlotterbeck

Laura Suter-Dick

Götz Schlotterbeck

The invention generally provides methods to determine the extent to which a compound interferes with steroid metabolism, comprising a novel biomarker of a felinine derivative. The invention also provides such novel felinine derivative biomarker.

Biomarker for farnesyl pathway

A method for processing a set of spectra, particularly NMR spectra, by selecting a principle spectral range, recording a plurality of principle spectra in the principal spectral range, obtaining a reference principal spectrum in the principal spectral range, carrying out, for each one of the principal spectra, a bin-wise division of the principal spectrum by the reference principal spectrum to obtain a corresponding set of spectral quotients; calculating, for at least one of the principal spectra, an associated set of statistical measures derived from the corresponding set of spectral quotients, and carrying out, for at least one of the sets of statistical measures, an outlier detection test.

Method for processing a set of spectra, particularly NMR spectra

For simultaneously determining the analytical NMR spectra of a number of samples placed suitably arranged in the measuring site of an NMR measuring apparatus, spatially and timely varying magnetic fields are used. The resulting signals are spatially resolved by a suited processing, for example Fourier transform. Surprisingly, from these signals, analytical NMRs of high resolution can be obtained for each sample. The method can be applied to two-dimensional arrangements of samples, for example a bundle of capillaries imitating a conventional NMR sample tube or a well plate, or three-dimensional arrangements, for example stacks of well plates. The method allows the determination of NMR spectra for analysis or for comparison with anterior spectra for long time behavior studies and quality assessment with only a fraction of time needed for measuring the samples individually.

Spectroscopic measurement method using NMR

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Windisch, Switzerland

Hans Senn