Roche Diagnostics Gmbh

Boehringer Mannheim Gmbh

Roche Diagnostics Operations, Inc.

Hans Schels

Horst Menzler

Ulrike Fischer

Peter Bendzko

Manfred Watzele

Karl-Heinz Mann

Bernd Buchberger

Gerd Kleinhammer

Thomas Metzler

Peter Kraft

Leonhard Geissler

Georg Kuffer

Hermann Bauer

Ute Fink

Jochen Kluge

Bernd Maciej

Rolf Reichhuber

Peter Wenzig

Device, method and kit for carrying out biochemical reactions, in particular for cell-free polypeptide biosynthesis composed of an external housing which encloses an inner housing with incorporated wells and a supply chamber, wherein the wells of the inner housing each contain a producing system during the biochemical reaction, the supply chamber contains a supply liquid during the biochemical reaction and the wells of the inner housing and the supply chamber are separated by a semipermeable membrane characterized in that the inner housing has at least two wells the lower ends of which are closed by a semipermeable membrane and the upper ends of which protrude from the supply liquid contained in the supply chamber, and is connected to means for moving and incubating the producing systems and to the supply liquid.

Method and device for carrying out biochemical reactions with a high throughput

The invention is a multichamber microdialysis device with a multitude of sample chambers in close side by side arrangement (similar to a microtiter plate) for receiving liquid samples, and at least one dialysate chamber for receiving a dialysate liquid. The sample chambers are surrounded by circumferential sidewalls and are in liquid exchange contact to a neighboring dialysis chamber via an exchange opening covered by a semipermeable membrane. The semipermeable membrane is fixed liquid-tight to the walls of the sample chamber, so that a diffusion exchange between the sample chamber and the correspondingly neighboring dialysate chamber is only possible via the membrane. Consequently, only molecules with a molecular weight below the molecular cut-off of the semipermeable membrane can diffuse from the sample chamber to the dialysate chamber or from the dialysate chamber to the sample chamber.

Multichamber microdialysis device

Bioreaction module for biochemical reactions

Dialyzer

Method and apparatus for carrying out biochemical reactions in particular for cell-free polypeptide biosynthesis. A bioreactor has, within a housing, a reaction chamber containing a producing system as well as a supply chamber separated from the reaction chamber by means of a semi-permeable membrane and containing a liquid serving as supply medium for the producing system. The supply chamber is subdivided within the bioreactor into a first partial chamber and a second partial chamber which are each connected to the reaction chamber via a semi-permeable supply membrane and which are connected to each other by means of a connection conduit. During the biochemical reaction, liquid is circulated from the first partial chamber of the supply chamber through the reaction chamber and into the second partial chamber of the supply chamber in such a fashion that, during each passage of liquid out of the first partial chamber into the reaction chamber, liquid simultaneously passes from the reaction chamber into the second partial chamber and liquid flows out of the second partial chamber via the connection conduit back into the first partial chamber.

Method and device for carrying out biochemical reactions

Device for pulling out or twisting off caps from vessels, wherein the vessel is held, and the cap is removed by means of a cap-holding device; the cap-holding device executes both a linear movement in direction of the vessel axis as well as a rotating movement around the vessel axis. The cap-holding device advantageously has several clamping jaws that are pressed against the circumference of the cap.

Device for removing or twisting off caps from vessels

The invention relates to a system for mixing a liquid with another liquid or a solid material by blowing a gas onto the surface of the liquid. The invention further relates to a system for implementing said method. Gas is blown onto the surface of the liquid from a distance which can be adjusted by determining the level of the liquid. A system of the invention, hence, comprises a device for blowing a gas onto the surface of a liquid and a device for detecting the level of a liquid.

Method and system for mixing liquids

Method for the contactless automatic mixing of a liquid reaction mixture in an analysis unit, in which the reaction mixture is located in a vessel accessible from above through an opening, by means of a gas jet escaping from an outlet opening of a mixing element, a rapid, effective and reliable non-invasive thorough mixing of the liquid is achieved by the mixing element being lowered at the start of the mixing operation in the direction of the liquid surface and the lowering movement being stopped in a bottom end position in which the mixing element projects into the vessel, but does not touch the liquid surface, the gas jet is switched on during the lowering of the mixing element, the gas jet is so aligned that it brings about an asymmetrical lowering of a part of the liquid surface in the vicinity of the vessel wall, and the gas jet has a rotational component of motion so that the lowered part of the liquid surface is set in rotation about the axis of the vessel.

Method and apparatus for the contactless automatic mixing of a reaction

Growing community of inventors

Munich, Germany

Hans Schels