Lts Lohmann Therapie-systeme Ag

Lts Lohmann Therapie-systeme Gmbh + Co. Kg

Lts Lohmann Therapie-systeme Gmbh

Other

Sandoz Gmbh

Klinge Pharma Gmbh

Schwarz Pharma Ag

Lts Lohmann Therapie Systeme Gmbh & Co.

Hf Arzneimittelforschung Gmbh

Lts Lohman Therapie-systeme Gmbh & Co. Kg

Lts Lohmann Therapie-systems Gmbh & Co. Kg

Ucb Pharma Gmbh

Hans-Rainer Hoffmann

Michael Horstmann

Thomas Hille

Rudolf Matusch

Bodo Asmussen

Walter Muller

Reinhold Meconi

Peter Lell

Michael Roreger

Malgorzata Kloczko

Detlev Neuland

Thomas Kissel

Klaus Schumann

Walter Müller

Mirko Kreh

Klaus Opitz

Robert-Peter Klein

Halvor Jaeger

Heinrich Kindel

Gunter Simon

Fritz Stanislaus

Henriette Schrank

Hans-Joachim Huber

Gerhard Schneider

Aria Baniahmad

Lothar Deurer

Andreas Koch

Karin Ludwig

Uwe Wortmann

Karsten Cremer

Peter Barth

Fritz Herrmann

Sandra Wiedersberg

Horst Dzekan

Harald List

Markus Müller

Reinhard Von Kleinsorgen

Robert P Klein

Joachim Moormann

Holger Piotrowski

Karin Wolter

Dorothea Steinborn

Axel Knoch

Hans M Wolff

Jurgen Maass

Gunter Cordes

Christa Nalbach

Axel Koch

Walter Muleer

Roman Hadaschik

A device for manufacturing a product from strip tape includes a roll that draws off and separates a web of material. The web of material is severed into individual strips in cooperation with a multiple circular knife roll. A vacuum conveyor channel is associated with each strip. The vacuum conveyor channel is designed such that each strip is turned on its way to the channel or through the channel by about 90&#xb0;. The end of the vacuum conveyor channel brings the strips together at one site to form a unit and at that site there are provided a guide and a transport device for the further transport to conversion equipment.

Process and device for manufacturing a product from strip tape, especially for manufacturing a medicinal and/or active substance-containing product as well as fillable containers or sealed-margin bags

A closure system for containers used for storing or administering substances in the form of liquids, pastes or powders that allows the container to be securely closed permanently and in a virus-proof, bacteria-proof and spore-proof manner. The container having an opening that is to be closed, a cap provided with a through-hole, the cap including a substantially cylindrical securing area, and a closure element for sealing the opening. The container includes an end face which surrounds the opening and on which the closure element bears. The closure element comprises a virus-proof, bacteria-proof and spore-proof film, and the cap comprises at least one closed, elastic sealing lip bearing resiliently in a direction towards the closure element in the operative position.

Closure system for containers

A method for isolating atraric acid from biological material, atraric acid derivatives, the chemical synthesis thereof, and the use of atraric acid and the derivatives thereof for treating or producing a medicament for treating benign prostate hyperplasia, prostate carcinoma or spinobulbar muscular atrophy is provided. In addition, a basic substance for the development of other agents used for treating benign prostate hyperplasia, prostate carcinoma, or spinobulbar muscular atrophy is provided.

Isolation of atraric acid, synthesis of atraric acid derivatives, and use of atraric acid and the derivatives thereof for the treatment of benign prostatic hyperplasia, prostate carcinoma and spinobulbar muscular atrophy

The invention relates to a needle-less, disposable injector comprising a housing (), which has at least one compression bar, a cylinder-piston unit (), a plunger-actuating ram (), a trigger unit () and a spring energy reservoir (), wherein the trigger unit locks the pre-tensioned spring energy reservoir by means of the compression bar. During triggering, the compression bar slides along at least one trigger element () of the trigger unit and, after triggering the trigger unit, the spring energy reservoir displaces the compression bar by means of the plunger-actuating ram and actuates the cylinder-piston unit. When loaded by the pre-tensioned spring energy reservoir, the pairing formed by the mutually facing inner wall of the trigger element and the contact surface of the compression bar has at least in areas a higher sliding friction coefficient than the pairing formed by the mutually facing collar surface of the plunger-actuating ram and the support surface of the compression bar. The present invention provides a disposable injector where the required minimum contact-pressure force is ensured during use thereof.

Disposable injector provided with high injector safety

A single-use injector is disclosed comprising a housing (), arranged in which are at least one mechanical spring energy store (), at least one piston-cylinder unit (), which can be effectively filled at least for a certain time, at least one piston-actuating ram () and at least one triggering unit (). The spring energy store comprises at least one pre-tensioned spring element. The spring-loaded piston-actuating ram () has at least one retaining rod or hook (), which can be moved transversely, at least in certain regions, and by means of a supporting portion supports the tensioned spring energy store on at least one resting surface of the housing. When actuation occurs, the triggering unit () releases the supporting portion to allow it to move away from the resting surface.

Single-use injector with at least one draw hook

A closure system is provided for containers used for storing or administering substances in the form of liquids, pastes or powders, which includes a cap, provided with a through-hole, and a closure element, wherein the cap holds the closure element with a force fit and/or form fit on the container, in the area of the container opening that is to be closed, by a catch element present on the container. The end face which surrounds the container opening, and on which the closure element bears, comprises a depression. The closure element is a virus-proof, bacteria-proof and spore-proof film that lies on the end face and, at least in some areas, over the depression. The cap is then fitted in place, an elastomer ring or adhesive ring is arranged between the closure element and the depression and fills the depression.

A cylinder/piston unit is disclosed for pre-fill, storage and release when desired of an active substance, such as a medicament. The cylinder/piston unit is provided with a cylinder and with a piston which is guided therein and which is sealed off in a sterile manner by a rubber seal, the cylinder and the piston enclosing a chamber that can be filled at least temporarily with active substance, and the cylinder having at least one discharge element at its front end. For this purpose, the piston resting in a rear position is sealed off relative to the cylinder in a sterile manner by a static front sealing element and by a static rear sealing element. Arranged spatially behind each static sealing element, there is a parking area for receiving the respective sealing element. When the piston is actuated, the individual static sealing elements are transferred from their respective sealing position into a parked position located in the parking area, and each sealing element in the parked position touches only the cylinder wall or only the piston wall. With the present invention, a cylinder/piston unit is developed which can be pre-filled and in which, despite a sterile sealing of the piston, only a slight force has to be applied in order to accelerate and/or move the piston.

Cylinder/piston unit with at least three sealing elements

The invention relates to a transdermal therapeutic system (TTS), preferably in the form of a transdermal plaster, that contains an active substance and an agent which can destroy the active substance. The TTS further includes a means of bringing the active substance, e.g. buprenorphine, and the agent, e.g. potassium permanganate, into contact when the TTS is removed from the skin of the patient, thereby causing the active substance to be destroyed.

Autodestructive transdermal therapeutic system

The invention relates to a biopsy needle for obtaining material for histological examination of body tissue, in particular, of bone marrow, or for the isolation, culture and modification of body cells, comprising a cannula with a cutting edge and a manual turning handle and a stylet running in the cannula. At the end of the cannula is an internal thread and preferably an outer thread. An easily visible marking is preferably provided on the manual turning handle. On withdrawing the biopsy needle the biopsy sample is thus held in position in the cannula and the advancing is precisely controllable.

Biopsy needle for the histological examination of body tissue

A one-way injector having a housing in which at least one mechanical spring energy store, at least one piston/cylinder unit, which can be at least temporarily filled with an active substance, at least one piston-actuating plunger and at least one tripping unit are arranged. To this end, the spring energy store comprises a preloaded spring element. The spring element is held in the preloaded position by a tension means surrounding at least a region of the spring. The tripping unit comprises a cutting tool which, in order to release the energy of the spring energy store, severs or weakens the tension means at least one point, the weakening immediately tearing the tension means. With the present invention, a one-way injector is developed which, with a small overall size, has only a few components and ensures reliable mounting and functioning with simple manipulation.

One-way injector with continuously charged spring energy store

A process for isolating N-butylbenzenesulfonamide (NBBS) from biological material, the chemical synthesis of benzenesulfonamide derivatives, the use of NBBS and benzenesulfonamide derivatives for treating benign prostatic hyperplasia and/or prostate carcinoma, the production of medicaments for the treatment thereof, and the use of NBBS and benzenesulfonamide derivatives as a lead substance in the development of active substances for treating benign prostatic hyperplasia and/or prostate carcinoma are provided.

[object Object]

Processes for the production of a compound of the following formula (I) by converting a compound of formula (II) with 2-pyrrolidone used in excess relative to compound (II) and processes for the production of a compound of formula (III). The latter process includes preparing compound (I); a reduction reaction which yields compound (III) in salt form; and liberating compound (III) from the salt.

Processes for the production of chinazoline alkaloids

A process for manufacturing a product from strip tape starting from a broad web of material includes the step of separating the web into individual strips with a smooth stripping roll, conveying each strip in a vacuum conveyor channel, turning the strips on their way to the channel or in the channel by about 90&#xb0;, leading the strips together at the end of the channel one upon the other and thereafter processing the strips to form the final product.

A process for manufacturing a product from strip tape starting from a broad web of material includes the step of separating the web into individual strips with a vacuum roll, conveying each strip in a vacuum conveyor channel, turning the strips on their way to the channel or in the channel by about 90&#xb0;, leading the strips together at the end of the channel one upon the other and thereafter processing the strips to form the final product.

Method and device for producing a product made of strip tape, especially a medical product and/or a product containing active substances as well as fillable receptacles or pouches whose edges can be sealed

The invention relates to porous, rapidly disintegrating, active substance-containing pellets based on chitosan or a basic chitosan derivative, manufactured according to a dripping method wherein an aqueous solution or dispersion of chitosan or a basic chitosan derivative, one or more active substances, possibly further active substances and an acid is dripped into a cooling liquid having a temperature of maximally &minus;5&deg; C., thereby causing solidification of the solution or dispersion in the form of droplets, and wherein the solidified droplets or pellets are isolated and dried. The invention further relates to the use of these pellets in the manufacture of medicaments or diagnostic agents.

Rapidly decomposing chitosan-based pellets

Growing community of inventors

Neuwied, Germany

Hans-Rainer Hoffmann