Eprova Ag

Hans R Mueller

Martin Ulmann

Josef Conti

Gunter Muerdel

Guenter Muerdel

The invention relates to a process for preparing (6S)-folinic acid and its salts by recrystallization of alkaline-earth salts of (6R,S)-folinic acid and, where necessary, liberation of the acid from the alkaline-earth folinates and/or, where necessary, conversion into the alkali salts by at least one recrystallization in the presence of a base. The invention also relates to calcium-, magnesium-, potassium- and sodium-(6S)-folinates and to (6S)-folinic acid prepared in accordance with the invention.

Sodium salt of (6S)-folinic acid

Pharmaceutical compositions containing (65)-folinic acid and salts

Process for separating folinic acid

A method for the resolution of (6R,S)-folinates into their diastereomers, comprising adding a water-soluble alkali metal, ammonium or alkaline earth metal salt of an inorganic or organic acid to an aqueous solution of a salt of (6R,S)-folinic acid, removing by filtration the salt which separates out, which consists predominantly of the corresponding (6R)-folinates, and isolating the desired (6S)-folinate from the filtrate.

Method for the resolution of folinic acid

Growing community of inventors

Schaffhausen, Switzerland

Hans R Mueller