B.m.r.a. Corporation B.v.

Debiopharm S.a.

Hans R Brunner

Daniel Hayoz

Ueli Haueter

Beat Steffen

Andreas Schaer

Juerg Nussberger

Jurg Nussberger

Thierry Pedrazzini

Bernard Waeber

A device for intermittent compression of human extremities such as, for instance, the region of the calves, to assist the return of body fluid in the direction of the heart. The device comprises a cuff and a pressure generator, which intermittently pressurizes the cuff, the cuff comprising in the direction of return a width of maximally 25 centimeters. The device further comprises a pressure generator that can be secured directly to the cuff or secured to the body or to clothing. This highly compact, handy configuration enables mobile application of the device in every-day situations to assist physical well-being.

Intermittent compression device

The present invention is directed to transgenic animals which have been engineered by homologous recombination to be deficient in the expression of the neuropeptide Y Y1 receptor. The invention encompasses the DNA constructs and engineered embryonic stem cells used to produce the animals, the transgenic animals themselves, and assays which utilize either the animals or tissues derived from the animals.

Transgenic mice with disrupted NPY Y1 receptor genes

The activity of angiotensin converting enzyme (ACE) is measured in biological samples as body fluids. ACE-activity is estimated in minimally diluted specimens, using the natural substrate angiotensin I at close to physiological concentration. Femtomoles of generated angiotensin II are trapped by specific high affinity monoclonal antibodies and thus protected from degradation by angiotensinases during the incubation step. The same antibodies are subsequently used for quantitation by radioimmunoassay.

Method for measuring the activity of angiotensin converting enzyme in

Preparation containing hexatriacontapeptides suitable for intravenous administration to human or other animal subjects are disclosed. such compositions are effective in treating life-threatening hypotension as encountered in bacteremic, anaphylactic or cardiogenic shock.

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Pully, Switzerland

Hans R Brunner