Intervet Inc.

Intervet International B.v.

Microbial Chemistry Research Foundation

Hans Peter Niedermann

Stephan Veit

Fritz Blatter

Michael Berger

Monika Brink

Alfred Stutz

Timo Rager

Ralf Warrass

Meinrad Brenner

Kerstin Fleischhauer

Heinz-Jorg Wennesheimer

Tanja Schweisel

Heiko Bothe

Tobias Kappesser

Guixian Hu

Heinz-Joerg Wennesheimer

Heinz-Jörg Wennesheimer

A process to prepare a compound of Formula (I) wherein R, Rand Rare each selected independently from hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxyl, and wherein the alkyl, alkenyl, alkynyl, and alkoxyl may be optionally substituted with one or more halogen, alkyl, alkenyl, alkynyl, and alkoxyl.

Process for preparing substituted crotonic acids

Disclosed is a method of making particles of a drug wherein use is made of diafiltration. The diafiltration can be with anti-solvent, in which case a precipitate is obtained of particles as such. The diafiltration can also be with a pharmaceutically acceptable suspension medium. In that case several process steps of isolating, drying, transporting of particles can be avoided, because the suspension resulting from the synthesis of the particles is directly turned into a final drug product formulation.

Use of liquid medium exchange by cross flow filtration in the preparation of drug suspensions

This invention relates to a method for making macrolides, and, in particular, a method for making optionally substituted 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide and derivatives thereof, as well as uses of macrolides to make medicaments, methods of treatment using macrolides, and methods for making intermediates that, inter alia, may be used to make macrolides. This invention also relates to solvated and non-solvated crystalline forms of 20,23-dipiperidinyl-5-O-mycaminosyl-tylonolide, as well as methods for making such crystalline forms, medicaments comprising (or derived from) such crystalline forms, methods for making medicaments comprising (or derived from) such crystalline forms, methods of treatment using such crystalline forms, and kits comprising such crystalline forms.

Macrolide synthesis process and solid-state forms

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Bubenheim, Germany

Hans Peter Niedermann