Aventis Pharma Deutschland, Gmbh

Sanofi-a Ventis Deutschland Gmbh

Hans-Peter Nestler

Hans Matter

Manfred Schudok

Herman Schreuder

Otmar Klingler

Gerhard Zoller

Anuschirwan Peyman

David William Will

Uwe Gerlach

Fahad A Al-Obeidi

Hauke Szillat

Marc Nazaré

The present invention relates to compounds of the formula I, in which R; Q; X; Q', D, Rand V have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of cardiovascular disorders like thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzymes factor Xa (FXa) and/or factor VIIa (FVIIa), and can in general be applied in conditions in which an undesired activity of factor Xa and/or factor VIIa is present or for the cure or prevention of which an inhibition of factor Xa and/or factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.

Guanidine and amidine derivatives as factor Xa inhibitors

Compounds of formula I, in which R, R, A, and B having the definitions set forth in the claims, are valuable pharmacologically active compounds, which exhibit a strong antithrombotic effect and are suitable, for example, for treating thromboembolic diseases and restenoses. They are reversible inhibitors of the blood clotting enzyme factor VIIa and can in general be applied in conditions in which an undesired activity of factor VIIa is present or for the cure or prevention of which an inhibition of factor VIIa is intended. Also disclosed are processes for the preparation of compounds of formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.

Malonamid and malonamic ester derivatives with antithrombotic activity, their preparation, and their use

Factor VIIa inhibitory (thio)urea derivatives, their preparation and their use

Urea derivatives with antiproteolytic activity

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Kelkheim, Germany

Hans-Peter Nestler