Hoffmann-la Roche Inc.

Hans-Peter M&auml;rki

Wolfgang Wostl

Eric Vieira

Volker Breu

Alfred Binggeli

Vincent Mutel

Daniel Bur

Geo Adam

Maurice Wilhelm

Manuela Hug

Marcel Meier

Piperidine derivatives, their manufacture and use as medicaments is described. The compounds are useful for treating diseases associated with restenosis, glaucoma, cardiac infarct, high blood pressure and end organ damage, e.g. cardiac insufficiency and kidney insufficiency.

Naphthalenyl piperidines as renin inhibitors

Naphthalenylmethoxypiperidines as renin inhibitors

The present invention provides orally administrable pharmaceutical compositions containing an inhibitor of gastrointestinal lipase, one (or more) additive(s) of the group consisting of substantially non-digestible, substantially non-fermentable, hydrophilic and/or hydrocolloidal food grade thickeners and emulsifiers, and auxiliary excipients. Methods are provided for preventing and treating anal leakage of oil in a patient by administering the compositions of the present invention to the patient.

Pharmaceutical compositions containing lipase inhibitor

The present invention is concerned with 1,2,4,5-tetrahydro-benzo&lsqb;d&rsqb;azepin derivatives as well as with their pharmaceutically acceptable salts in their racemic and optically active form, which compounds are antagonists at metabotropic glutamate receptors and therefore useful for the treatment of diseases related to these receptors.

1,2,4,5-Tetrahydro-benzo&lsqb;D&rsqb;azepin derivatives

Piperidine derivatives

Growing community of inventors

Basel, Switzerland

Hans-Peter Märki

Growing community of inventors

Basel, Switzerland

Hans-Peter M&auml;rki

Hans-Peter Märki