Bayer Aktiengesellschaft

Hans-Peter Krause

Delf Schmidt

Rudiger Sitt

Hilmar Bischoff

Peter Fey

Rolf Angerbauer

Hans-Joachim Kabbe

Walter Hubsch

Thomas Philipps

Lutz Muller

Bodo Junge

Jurgen Stoltefuss

Walter Puls

Jorg Petersen Von Gehr

Werner Frommer

Walter H&uuml;bsch

J&ouml;rg Petersen Von Gehr

Ulrich Heber

Jorg Peterson-von Gehr

Thomas Philipps, Deceased

Substituted triols are prepared by reducing appropriately substituted carboxylic esters. The substituted triols can be used as active substances in medicaments.

Substituted triols

Substituted 4-phenyl-pyridones and 4-phenyl-2-alkoxypyridines are prepared by reducing corresponding 4-phenyl-pyridone and 4-phenyl-2-alkoxypyridine derivatives. The substituted 4-phenyl-pyridones and 4-phenyl-2-alkoxypyridines can be employed as active compounds in medicaments, in particular for the treatment of hyperlipoproteinaemia.

Substituted 4-phenyl-pyridones and 4-phenyl-3-alkoxypyridines

New substituted pyridines are prepared by reducing suitably substituted pyridine derivatives. The new substituted pyridines are suitable as active compounds in pharmaceuticals, in particular for the treatment of hyperlipoproteinaemia.

Substituted pyridines

The invention relates to alkylurea derivatives of Formula (I), as defined in the specification, which alkylurea derivatives are useful as hypolipaemic agents. Also included in the invention are methods for the manufacture of said alkylurea derivatives compositions and medicaments containing said alkylurea derivatives and methods for the use of said alkylurea derivatives.

Lipid absorption-inhibiting agents and their use

Bisindolyl alkylene ureas lipid absorption-inhibiting agents and their

Lipid absorption-inhibiting 1,4-benzothiazines

The invention relates to 3,4,5-trihydroxypiperidine compound of Formula (I) as methods for the preparation of said compounds. Also included in the invention are compositions containing said piperidine compounds and methods for the use of said piperidine compounds and compositions. The invention further includes veterinary compositions containing said piperidine compounds and their use in animal nutrition.

N-phenoxy(or thio)hydrocarbon 3,4,5-trihydroxypiperidine derivatives,

According to the present invention inhibitors for glycoside hydrolases, and in particular glucosidase inhibitors especially saccharase inhibitors, which are active in the digestive tract are formed by culturing organisms of the family Bacillaceae, particularly by strains of the genus Bacillus. It has also been found that certain strains of organisms of the family Bacillaceae, especially strains DSM 7, DSM 704 and DSM 675 produce the antibiotic known as 1-desoxynojirimycin. The invention therefore provides a method of producing 1-desoxynojirimycin which comprises culturing a 1-desoxynojirimycin producing organism of the genus Bacillus. Inhibitors for glycoside hydrolases and the invention includes methods for producing such inhibitors, pharmaceutical compositions containing the inhibitors and methods of treatment involving the use of the inhibitors.

Inhibitors, obtained from bacilli, for glycoside hydrolases

The present invention provides amino-sugar derivatives of the general formula ##STR1## in which n and m independently of each other represent an integer from 0 to 8 and the sum n+m has a value of 0 to 8, and X designates a group --OR, --SH, --SR, --NH.sub.2, --NHR or NRR.sub.1, in which R designates an alkyl, alkenyl, cycloalkyl, aralkyl, aryl or heterocyclic radical, which can be substituted, and R.sub.1 designates an alkyl, cycloalkyl, aralkyl or aryl radical, which can be substituted, or R and R.sub.1 together with the nitrogen atom to which they are bonded, form a heterocyclic ring. It has been found that the compounds of the formula (II) are highly active inhibitors for glycoside hydrolases of the digestive tract. Also included in the invention are methods of preparing the amino-sugar derivatives of the invention, compositions containing said amino-sugar derivatives and methods for the use of said amino-sugar derivatives and compositions containing them.

Amino-sugar derivatives, process for their preparation and

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Wuppertal, Germany

Hans-Peter Krause