Roche Diagnostics Operations, Inc.

Roche Diagnostics Gmbh

Boehringer Mannheim Gmbh

Other

Roche Molecular Systems, Inc.

Hitachi High-Tech Corporation

Universitaet Bern

Securetec Detektions-Systeme Ag

F. Hoffmann-La Roche Ag

Universitât Bern

Hans-Peter Josel

Dieter Heindl

Rupert Herrmann

Luisa De Cola

Christoph Seidel

Jesus Miguel Fernandez Hernandez

Robert Cysewski

Christian Klein

Frank Bergmann

Michael Gerg

Giuseppe Prencipe

Uwe Kobold

Thomas Froehlich

Eloisa Lopez-Calle

Stefanie Froehner

Martin Rempt

Sebastian Dziadek

Simon Ferdinand Loibl

Jelena Milic

Erasmus Huber

Herbert Andres

Andreas Leinenbach

Gabriele Punzmann

Silvia Baecher

Martin Egger

Christian Weilke

Elena Longhi

Nicole Pirkl

Anna-Skrollan Geiermann

Herbert Von Der Eltz

Carina Horn

Michael Schraeml

Thomas Meier

Toralf Zarnt

Gregor Sagner

Stefan Quint

Jutta Arden-Jacob

Gion Calzaferri

Michaela Windfuhr

Josef Roedl

Beatus Ofenloch-Hahnle

Reinhold Hilpert

Josef Ritter

Oliver Larbolette

Ewelina Hegel

Klaus Hirzel

Florian Binder

Michael Busby

Rupert Hermann

Rainer Beckert

Gunter Lampert

Rosa Isabel Saez Diaz

Thomas Fischer

Helmut Lenz

Elke Faatz

Barbara Upmeier

Juergen Spinke

Josef Maier

Waltraud Ankenbauer

Eva Hoess

Karl-Heinz Drexhage

Rudolf Seibl

Martin Gutekunst

Axel Schmidt

Ursula-Henrike Wienhues

Klaus Muhlegger

Rudolf Vogel

Hartmut Merdes

Gunter Pappert

Leopold Von Proff

Frederic Donie

Josef Burg

Benjamin Tiemann

Hannes Kuchelmeister

Martina Junius-Comer

Tobias Oelschlaegel

Norbert Franken

Ursula Klause

Ada Goerlach-Graw

Dirk Kessler

Jürgen Spinke

Bruno Zink

Wolfgang Jenni

Eva Höss

Bernhard Eckert

Christian Vogl

Noah Weiss

Lars Hillringhaus

Edgar Voss

Jorg Issberner

Bernd Hilger

Thomas Welzel

Fritz Vogtle

Joachim Hones

Gaston Hubertus Maria Vondenhoff

Helmut Oberpriller

Waldemar Adam

Karl Heinz Drexhage

Christoph Mueller

Harald Ertl

An analysis method includes: an inflow process of a solution containing a test object, a magnetic support on the surface of which a complex including an antibody labeled with a luminescent agent and recognizes the test object is formed, and a reaction aid to assist reaction of the luminescent agent in a flow cell; a process of capturing the magnetic support over a working electrode by a magnetic field; a process of making the luminescent agent illuminate by applying a voltage to the working electrode; and a process of measuring an amount of luminescence of the luminescent agent. The luminescent process includes: luminescence from action of a first neutral radical, produced from the reaction aid through a cation radical; and luminescence from action of a second neutral radical, produced not through a cation radical, on the luminescent agent. This increases the luminous efficiency of ECL and enhances detection sensitivity.

Biomolecular analysis method and biomolecular analyzer

The present invention relates to reagents which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said reagents.

Reagent for mass spectrometry

The present invention relates to compounds which are suitable to be used in mass spectrometry as well as methods of mass spectrometric determination of analyte molecules using said compounds.

Benzylpyridinium reagent for mass spectrometry

The disclosure concerns methods for the detection of an analyte in a sample by electro-chemiluminescence using new reagent compositions. New reagent compositions, reagent kits for measuring electrochemiluminescence (ECL) and electrochemiluminescence detection methods using the new reagent compositions are disclosed. In particular, the disclosure relates to the use of novel combinations of compounds which can be used in said measurements to provide improved assay performance.

Branched-chain amines in electrochemiluminescence detection

The present invention relates to a monoclonal antibody capable of binding to biotin. In one embodiment the monoclonal antibody according to the invention also does not bind to a biotin moiety on a biotinylated molecule, wherein the biotin moiety is attached to the molecule via the carbon atom of the carboxyl function of the valeric acid moiety of biotin. Also disclosed is a method for generation of an antibody as discloed herein. The monoclonal antibody according to the invention is of specific use in a method for measuring an analyte in a sample, wherein a (strept)avidin/biotin pair is used to bind a biotinylated analyte specific binding agent to a (strept)avidin coated solid phase.

Biotin-specific monoclonal antibody and use thereof

The present invention relates to a method of immobilizing a cell on a support, the method comprising a) providing a compound or salt thereof comprising, preferably consisting of, one or more hydrophobic domains attached to a hydrophilic domain, wherein the one or more hydrophobic domains are covalently bound to said hydrophilic domain, and wherein the one or more hydrophobic domains each comprise a linear lipid, a steroid or a hydrophobic vitamin, and wherein the hydrophilic domain comprises a polyethylene glycol (PEG) moiety, and wherein the compound comprises a linking group; b) contacting a cell with the compound under conditions allowing the interaction of the compound with the membrane of the cell, thereby immobilizing the linking group on the surface of the cell; and c) contacting the linking group immobilized on the cell with a support capable of binding the linking group, thereby immobilizing the cell on the support.

Method of immobilizing a cell on a support using compounds comprising a polyethylene glycol moiety

The present invention concerns an in vitro method for measurement of 25-hydroxyvitamin D, wherein the potentially interfering compound 24,25-dihydroxyvitamin Dis blocked by a binding agent specifically binding to 24,25-dihydroxyvitamin Dand not binding to 25-hydroxyvitamin D.

Method for measurement of vitamin D

The present disclosure relates to an in vitro method for releasing analytes from a sample involving contacting the sample with (i) a chaotropic agent, (ii) an organic solvent, (iii) a detergent, and (iv) at least one agent providing bicarbonate ions. The present disclosure further relates to a release agent for releasing analytes from a sample having the aforesaid compounds. Moreover, the present disclosure relates to uses, kits, methods and devices related to the method and the release agent of the present disclosure.

Generic pretreatment reagents for analyte determinations

The present disclosure relates to novel multifunctionalized silicon nanoparticles, to processes for their preparation and to compositions comprising the novel multifunctionalized silicon nanoparticles. The disclosure also relates to the use of the novel multifunctionalized silicon nanoparticles in electrochemiluminescence based detection methods and in the in vitro detection of an analyte. In particular, the disclosure relates to methods for measuring an analyte by in vitro methods employing the novel multifunctionalized silicon nanoparticles.

Multifunctionalized silicon nanoparticles, process for their preparation and uses thereof in electrochemiluminescence based detection methods

The disclosure concerns methods for the detection of an analyte in a sample by electrochemiluminescence using new reagent compositions. New reagent compositions, reagent kits for measuring electrochemiluminscence (ECL) and electrochemiluminescence detection methods using the new reagent compositions are disclosed. In particular, the disclosure relates to the use of novel combinations of compounds which can be used in said measurements to provide improved assay performance.

The present invention relates to the use compounds comprising two or more hydrophobic domains and a hydrophilic domain comprising a polyethylene glycol (PEG) moiety for stabilization of a cell, and methods related thereto.

Use of compounds comprising two or more hydrophobic domains and a hydrophilic domain comprising PEG moieties for stabilization of a cell

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Weilheim, Germany

Hans-Peter Josel