Genentech, Inc.

Hans-Peter Gerber

Wei-Ching Liang

Sachdev Singh Sidhu

Germaine G Fuh

Christian Wiesmann

Frederic Fellouse

Napoleone Ferrara

Xiao Huan Liang

Stuart Bunting

Daniel Eric Sherman

Joe Kowalski

Maria Teresa Pisabarro

Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with na&#xef;ve libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.

Anti-VEGF antibodies

The present invention is directed to methods and means for making and using Angptl3 polypeptides. The invention specifically concerns the use of Angptl3 polypeptides in inducing liver regeneration and angiogenesis. Further methods include the use of Angptl3 polypeptides in the diagnosis and treatment of liver disease. Also provided herein are antibodies which bind to the polypeptides of the present invention.

Composition comprising and method of using angiopoietin-like protein 3 ANGPTL3

Anti-VEGF antibodies and variants thereof, including those having high affinity for binding to VEGF, are disclosed. Also provided are methods of using phage display technology with naive libraries to generate and select the anti-VEGF antibodies with desired binding and other biological activities. Further contemplated are uses of the antibodies in research, diagnostic and therapeutic applications.

Composition comprising and method of using angiopoietin-like protein 3 Angptl3

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Bellevue, WA, United States of America

Hans-Peter Gerber