Merck Patent Gmbh

Merck Patent Gesellschaft MIT Beschrankter Haftung

Merck Patent Gesellschaft MIT Beschraenkter Haftung

Merck Patent Gesellschaft

Merk Patent Gmbh

Ryvu Therapeutics S.a.

Marck Patent Gmbh

Hans-Peter Buchstaller

Dieter Dorsch

Christian Sirrenberg

Frank Zenke

Christiane Amendt

Ulrich Emde

Hans-Michael Eggenweiler

Dirk Finsinger

Werner Mederski

Matthias Wiesner

Matthias Grell

Michael Wolf

Thomas Fuchss

Kai Schiemann

Timo Heinrich

Margarita Wucherer-Plietker

Oliver Schadt

Wolfgang Staehle

Lars Thore Burgdorf

Christina Esdar

David Bruge

Alfred Jonczyk

Hanns Wurziger

Joachim Gante

Guido Melzer

Frank Stieber

Manfred Baumgarth

Wilfried Rautenberg

Sabine Bernotat-Danielowski

Horst Juraszyk

Birgitta Leuthner

Joerg Bomke

Markus Klein

Hartmut Greiner

Guenter Hoelzemann

Bertram Cezanne

Joachim Leibrock

Gérard Moinet

Rudolf Gottschlich

Ansgar Wegener

Oliver Poeschke

Soheila Anzali

Felix Rohdich

Christian Noe

Matthias Leiendecker

Michael Berger

Leiendecker Matthias

Chirstina Esdar

Thiophene derivatives

Compounds of the formula Ia or of the formula Ib in which X, Y, Rand Rhave the meanings indicated in Claim, are inhibitors of pyruvate dehydrogenase kinase (PDHK), and can be employed, inter alia, for the treatment of diseases such as cancer.

Bicyclic heterocyclic derivatives

The invention relates to novel compounds of the formula (I) which can be used for the inhibition of serine-threonine protein kinases and for the sensitisation of cancer cells to anticancer agents and/or ionising radiation.

Arylquinazolines

Compounds of the formula I in which X, Q, Rand Rhave the meanings indicated in Claim, are inhibitors of pyruvate dehydrogenase kinase (PDHK), and can be employed, inter alia, for the treatment of diseases such as cancer.

Piperidinyl-propanone derivatives

Compounds of the formula I in which Z, W, Q, R and Y have the meanings indicated in claim, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.

1,4-dicarbonyl-piperidyl derivatives

Compounds of the formula Ia or of the formula Ib in which X, Y, Rand Rhave the meanings indicated in claim, are inhibitors of pyruvate dehydrogenase kinase (PDHK), and can be employed, inter alia, for the treatment of diseases such as cancer.

Compounds of the formula I in which X, Y, Rand Rhave the meanings indicated in Claim, are inhibitors of pyruvate dehydrogenase kinase (PDHK), and can be employed, inter alia, for the treatment of diseases such as cancer.

Piperidinyl derivatives

The invention relates to novel compounds of the formula (I) which can be used for the inhibition of serine-threonine protein kinases and for the sensitization of cancer cells to anticancer agents and/or ionizing radiation.

Compounds of the formula I in which R-Rand Z have the meanings indicated in Claim, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.

Oxoquinazolinyl-butanamide derivatives

Compounds of the formula I in which W, X and Y have the meanings indicated in Claim, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.

Heterocyclyl-butanamide derivatives

Compounds of the formula I in which R-Rhave the meanings indicated in Claimare inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.

Piperidine urea derivatives

Compounds of the formula (I) in which R, Rand Rhave the meanings indicated in claim, are inhibitors of pyruvate dehydrogenase kinase (PDHK), and can be employed, inter alia, for the treatment of diseases such as cancer. 

N1-(3,3,3-trifluoro-2-hydroxo-2-methylpropionyl)-piperidine derivatives as inhibitors of pyruvate dehydrogenase kinase

Compounds of the formula I in which R, X and n have the meanings indicated in Claim, are inhibitors of Tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.

Phthalazine derivatives

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Griesheim, Germany

Hans-Peter Buchstaller