Bayer Aktiengesellschaft

Merck Patent Gesellschaft MIT Beschrankter Haftung

Behringwerke Aktiengesellschaft

Max-delbruck-centrum Fur Molekulare Medizin

Hans Paulsen

Peter Stadler

Cenek Kolar

Franz-Georg Hanisch

Polkhard Iodter

Rolf Jansen

Jean C Jacquinet

Tumor vaccines for the use against MUC1 positive carcinomas are presented. A tumor vaccine containing synthetic peptides comprising sequences of the human epithelial mucin MUC1 containing the immunodominat region PDTRPAP which is glycosylated at the threonine. Preferred glycosylation of the immunodominant region is a O-glycosidically linked a-N-acetylgalactosamine (GalNAc) or short chained oligosaccharides. The present invention can be used on all MUC1-positive carcinomas.

Tumor vaccines for MUC1-positive carcinomas

The text describes compounds having the formula I ##STR1## wherein R.sup.1 denotes a hydrogen atom or an acyl or benzyl protective group, R.sup.1 and R.sup.2 together denote an alkylidene or benzylidene protective group, R.sup.2 and R.sup.3 denote hydrogen atoms or acyl or benzyl protective groups or a .beta.-galactopyranosyl radical or a 2,3,4,6-tetra-0-acetylated derivative thereof, R.sup.4 denotes an azido, amino or acetamido group, R.sup.5 denotes --0--alkyl, --0--aryl, --0--benzyl, --NHNH.sub.2, --N.sub.3 or --OH and n denotes 1 to 10, and also a process for their preparation and their use as antigens or immunoadsorbents.

Chemical compounds, aminoacid attached to glycoside

A process for the preparation of garamine and garamine derivatives of the formula (I) ##STR1## wherein the radicals R.sup.1 are each H or amino-protecting groups and the radicals R.sup.2 are each H or hydroxyl-protecting groups, comprises selectively cleaving in a strong acid a compound of formula (II) or a mixture thereof ##STR2## wherein R.sup.3 is acyl, R.sup.4 and R.sup.5 are each H or CH.sub.3 and R.sup.1 and R.sup.2 are the same as in formula (I).

Process for the preparation of garamine and garamine derivatives

The invention provides pseudo-disaccharides (and their salts) and a method for their preparation. The pseudo-disaccharides are useful as intermediates for the preparation of antibiotics and are also useful as antimicrobial agents, particularly against Gram-negative bacteria.

Growing community of inventors

Hamburg, Germany

Hans Paulsen