Basf Aktiengesellschaft

Hans P Albrecht

Horst Kreiskott

Manfred Raschack

Gerda Von Philipsborn

Ludwig Friedrich

Frank Zimmermann

Hans U Siebeneick

N-acyl derivatives of dipeptides of the formula

N-acyl derivatives of dipeptides, their preparation and their use in the

Novel N-acyl derivatives of peptides related to L-pro-L-leu-gly-NH.sub.2, melanocyte stimulating hormone-release inhibiting factor (MIF), and therapeutic compositions which are useful for the treatment of depression.

N-acyl derivatives of peptides, their preparation and their use in the

4,5-methano-bufadienolide-rhamnosides of the formula I ##STR1## where R.sup.1 is hydrogen or alkyl or acyl of 1 to 4 carbon atoms, R.sup.2 and R.sup.3 are identical or different and each is hydrogen or alkyl or acyl of 1 to 4 carbon atoms, or both together are ##STR2## where R.sup.4 and R.sup.5 are identical or different and each is hydrogen or alkyl or alkoxy of 1 or 2 carbon atoms. The novel compounds may be used for counteracting cardiac insufficiency.

4,5-Methano-bufadienolide-rhamnosides, their preparation, and drugs

Hypolipemic non-glycosidic theophylline-sugar compounds having the formula ##STR1## are disclosed, as are a method for making them and methods and compositions for treating hyperlipemia with the compounds.

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Weinheim, Germany

Hans P Albrecht