Merck Patent Gmbh

Merck Patent Gesellschaft

Merck Patent Gesellschaft MIT Beschrankter Haftung

Merck Patent Gesellschaft MIT Beschraenkter Haftung

Hans-Michael Eggenweiler

Michael Wolf

Norbert Beier

Hans-Peter Buchstaller

Pierre Schelling

Rochus Jonas

Christian Sirrenberg

Michael Gassen

Thomas Ehring

Guenter Hoelzemann

Maria Christadler

Thomas Welge

Dieter Dorsch

Joachim Leibrock

Srinivasa R Karra

Bertram Cezanne

Paul Czodrowski

Oliver Pöschke

Harry Schwartz

Compounds of the formula (I) in which R, Rand X have the meanings indicated in claim, are inhibitors of TBK1 and IKK&#x3b5; and can be employed, inter alia, for the treatment of cancer and inflammatory diseases

Pyridine-and pyrazine derivatives

Compounds of the formula (I) in which R, R, X and Y have the meanings indicated in claim, are inhibitors of TBK1 and IKK&#x3b5; and can be employed, inter alia, for the treatment of cancer and inflammatory diseases.

3-Cyanoaryl-1H-pyrrolo[2,3-B] pyridine derivatives

Compounds of the formula I, in which R, R, X and Y have the meanings indicated in Claim, are inhibitors of TBK1 and IKK&#x3b5; and can be employed, inter alia, for the treatment of cancer and inflammatory diseases.

Benzonitrile derivatives as kinase inhibitors

Novel quinazolinamide derivatives of the formula (I), in which R1-R43 and X have the meanings indicated in Claim, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.

Phenylquinazoline derivatives

Novel indazole derivatives of the formula (I), in which R-Rhave the meanings indicated in Claim (), are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role. 

Indazole derivatives for the treatment of HSP9O-induced diseases

Novel triazole derivatives of the formula (I), in which R-R, and Y have the meanings indicated in claim, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role. 

Triazole derivatives

Novel quinazolinamide derivatives of the formula (I), in which R-Rand X have the meanings indicated in Claim, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.

Quinazolinamide derivatives

Novel quinazolinamide derivatives of the formula (I), in which R-Rhave the meanings indicated in Claim, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role.

Novel triazole derivatives of the formula (I) in which R-Rand Y have the meanings indicated in Claim, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role. 

Triazole derivatives II

The invention relates to novel thienopyridine derivatives of formula (I), wherein R1, R2, R3, R4 and Y have the meaning cited in claim, are HSP90-inhibitors and can be used for producing a medicament for treating illnesses, wherein the inhibition, regulation and/or modulation of HSP90 plays a roll. 

Thienopyridines

Novel adenine derivatives of the formula (I), in which R, R, R, X and Y have the meanings indicated in Claim, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role. 

Adenine derivatives

Novel phenylquinazoline derivatives of the formula (I), in which R, R, R, Rand Rhave the meanings indicated in Claim, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role. 

2-amino-4-phenylquinazoline derivatives and the use thereof as HSP90 modulators

Novel thienopyridine derivatives of the formula (I), in which R, R, Rand Y have the meanings indicated in claim, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role. 

Thienopyridine derivatives and the use thereof as HSP90 modulators

Novel 1,5 diphenylpyrazole derivatives of the formula (I), in which R-Rhave the meanings indicated in Claim, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role. 

1,5-diphenylpyrazoles

Novel 1,5-diphenylpyrazole derivatives of the formula (I) in which R-Rhave the meanings indicated in claim 1, are HSP90 inhibitors and can be used for the preparation of a medicament for the treatment of diseases in which the inhibition, regulation and/or modulation of HSP90 plays a role. 

Growing community of inventors

Darmstadt, Germany

Hans-Michael Eggenweiler