Behringwerke Aktiengesellschaft

Aventis Behring Gmbh

Hans M Preis

Norbert Heimburger

Gerhardt Kumpe

Wilfried Wormsbacher

Horst Schwinn

Peter Fuhge

Helmut Heber

Hermann Pelzer

Horst Naumann

Wilfried Wormsb&auml;cher

The present invention relates to a process for the preparation of a product of blood coagulation factors II, VII, IX and X which is virtually free of virus, the process comprising heating an aqueous liquid containing these factors in the presence of calcium ions and a chelating agent and, optionally, an amino acid, a saccharide or sugar alcohol, antithrombin III and/or heparin. The product can be used for the treatment of blood coagulation disorders.

Process for the pasteurization of plasma or concentrates of blood coagulation factors II, VII, IX and X

A pasteurized human firbinogen which can be used therapeutically, and a process for its preparation are described.

Pasteurized human fibrinogen (HF), a process for its preparation, and

The invention relates to a process for the preparation of C1 inactivator, which, if appropriate, is hepatitis-free and, if appropriate, can be lyophilized, and its use as a medicament.

Process for the preparation of the C1 inactivator

A process for the pasteurization of antihemophilic cryoprecipitate (AHC) is described, wherein AHC is heated in the presence of calicum ions, an amino acid and a carbohydrate. The pasteurized AHC is used for the treatment of coagulation disturbances.

Process for the pasteurization of antihemophilic cryoprecipitate (AHC)

What is disclosed is a method for treating a preparation containing blood clotting Factors II and/or VII to render it virtually hepatitis-free by warming said preparation in the presence of a chelating agent and in the further presence of an amino acid and/or a saccharide or sugar alcohol.

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Marburg, Germany

Hans M Preis