Case Western Reserve University

Other

Hans Luders

Dominique M Durand

Jonathan Jay Miller

Ken Loparo

Farhad Kaffashi

Mohamad Koubeissi

Mehdi Hamaneh

Tanvir U Syed

John Turnbull

Samden Lhatoo

Example apparatus and methods cause activation of target neural tissue through electrical stimulation of a connected white matter tract to reduce the hyper-excitability of the target neural tissue and thus reduce seizures while preserving memory in humans. Example apparatus and methods apply low frequency (e.g., &#x3c;10 HZ) electrical stimulation to the forno-dorso-commissure (FDC), detect an electrical signal generated in an area connected to, innervated by, or that can be activated by the FDC in response to the stimulation, and reconfigure the stimulation based on the detected signal and a desired therapeutic effect. The stimulation may be reconfigured to produce an electrical stimulation waveform that will produce the desired therapeutic effect. The desired therapeutic effect may be, for example, reducing hyper-excitability of neural tissue in a target area, reducing hippocampal spikes, reducing seizure odds, or improving recall.

Stimulation of the forno-dorso-commissure (FDC) for seizure suppression and memory improvement

A system or method can facilitate source localization of brain electrical activity. In one example, an expert system can be utilized to evaluate the source localization results and, based on the acceptability of the results, adjust a data preparation phase to provide for acceptable source localization.

Expert system to facilitate source localization of brain electrical activity

Systems and methods can be used to help discriminate between epileptic and non-epileptic seizures based on a relationship between the postictal heart electrical activity and the preictal heart electrical activity. Also disclosed is an approach to determine an R-R interval by using a time-invariant complex wavelet transform.

System, apparatus and method for diagnosing seizures

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Cleveland, OH, United States of America

Hans Luders