Glatt Maschinen-und Apparatebau Ag

Pharmatronic Ag

Asulab S.a.

Glatt Gmbh

Hans Leuenberger

Bernhard Luy

Reinhard Nowak

Stephan Buchmann

Jurg M Studer

Claudia Reinke

Georgios Imanidis

Stefan Winzap

Armin Karl Theodor Prasch

Sabina Strausak

Armin K T Prasch

In the method for producing a particulate material ( ) from an at least partially liquid material ( ) containing a solvent and/or dispersant, this material ( ) is atomized in a process chamber ( ) into droplets which are frozen to particles ( ) by contact with a freezing fluid. The particles ( ) are then dried by freeze-drying in the or in another process chamber ( ) having a filter ( ) at the top. For the freeze-drying, cooled process gas is passed upward from below through the process chamber ( ) and through the filter ( ) in such a way that at least a substantial part of the particles ( ) rest against the filter ( ) at least for a substantial part of the freeze-drying taking place in the process chamber ( ). This makes it possible to dry a batch of particles ( ) in a short time.

Method for producing particulate goods

A device for delivering a medicament has a membrane (7) with at least one permeable area (7b) permeable to the medicament and a reservoir space (25) which contains a solvent and the medicament at least partially dissolved therein, An adjustable and/or deformable control element (7) is disposed on the side of the membrane (7) facing the reservoir space (25) with which the access of the medicament from the reservoir space (25) to at least one permeable area (7b) of the membrane (7) can be changed. In addition an electronic device (37) is provided with which the control element (17) can be automatically controlled via a motor (37). The device permits the periodic alteration of the delivery rate of the medicament which is advantageous in many cases.

Device for delivering a medicament

Method and system for agglomerating particles and/or for coating

The system for testing the diffusion behavior of a substance comprises a donor compartment detachably mounted on a holding member of a rotor, rotatably around a vertical axis, said donor compartment being bounded at its bottom by a membrane effective to separate the donor compartment from an acceptor compartment. The membrane comprises a flexible carrier of a bio-compatible, lifeless, light permeable material, on which cells constituting a monocellular layer have been cultivated, for example. By determining the time dependent variation of the quantity of a substance passing through the membrane by diffusion, it is possible to determine the coefficient of diffusion and/or the coefficient of permeability of the membrane and of the cell culture provided thereon. By suitable selection of the cells, conditions may be created that closely resemble those that occur during the absorption of the respective substance through the biophase of a living organism.

Membrane, system and process for testing substance diffusion through the

A particulate material containing particles to be agglomerated and/or provided with a coating is introduced in batches into a space bounded by a container, in which a gas, in particular air, is passed through the particles. The particles are set in motion, for instance by the gas, such as in whirling motion, to form a whirling, layer. The particles are wetted by means of a mixture consisting of a gas and the vapor of a wetting agent. This mixture is introduced into the space containing the particles, and cold gas and a mixture of warm gas and wetting agent are supplied for example, alternately. In this manner, the particles may be wetted uniformly and relatively fast, and held at a relatively low temperature. This is of considerable advantage when processing thermolabile materials.

Process of treating a particulate material and apparatus for

The particles of the particulate material to be dried are cooled before the drying operation proper, or in the initial phase thereof, to a temperature low enough to make the liquid to be extracted solidify. At least the drying operation proper is carried out in a space bounded by a container, in which a gas, more particularly air, is passed through the particles. While in said space, the particles are subjected to motion, for example, they are whirled by the gas to form a whirling layer. The temperature of the gas is adjusted to have at least a considerable part of the drying operation take place by sublimation, the heat energy required for the sublimiation being supplied to the particles at least in part by the gas passed through them. In this way, the particulate material may be dried with care and nevertheless in relatively large batches, and with limited time expenditure.

Process of drying a particulate material and apparatus for implementing

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Pfeffingen, Switzerland

Hans Leuenberger