Sandoz Gmbh

Novartis Ag

Hans Kobel

Roland M Wenger

Pietro Bollinger

Dieter Seebach

Hans Tscherter

Georg Bolliger

Rene P Traber

Brigitte Besemer-Rosenwirth

Soo Young Ko

Jean-Jacques Sanglier

Hans Hofmann

Johann J Bolsterli

Ren&eacute;P Traber

It has been found that nonimmunosuppressive, cyclophilin-binding cyclosporins are useful in the treatment and prevention of AIDS and AIDS-related disorders. Such cyclosporins include novel Ciclosporin derivatives modified at the 4- and/or 5-positions.

Cyclosporin fermentation process

Cyclosporins

Nonimmunosuppressant cyclosporin derivatives having cyclophilin-binding activity, for example, the compound, �MeIle!.sup.4 -ciclosporin, are useful in inhibiting HIV-1 replication in treating AIDS and AIDS related disorders.

9-thia ergot cyclic peptide alkaloids produced by fermentation or synthetic methods have interesting anti-parkinson and other pharmacological activities.

Ergot cyclic peptide alkaloids having a venotonizing effect, useful for

Use of thio isosteres of ergot peptide alkaloids as vasaconstrictors

Cyclosporins wherein the amino acid residue at the 8-position is a (D)-acyloxy-.alpha.-amino acid residue, typically of formula ##STR1## wherein X=-MeBmt- or -dihydro-MeBmt-, Y=-.alpha.Abu-, -Ala-, -Thr-, -Val- or -Nva-, Z=-Val- or -Nva- and Q=R.sub.1 --CO--O--CH(R.sub.2)--CH(CO--)--NH--wherein R.sub.1 =H, C.sub.1-4 alkyl or phenyl and R.sub.2 =H or CH.sub.3, possess immunosuppressive, anti-inflammatory and anti-parasitic activity.

Novel cyclosporins

9-Thia ergot cyclic peptide alkaloids produced by fermentation or synthetic methods have interesting anti-parkinson and other pharmacological activities.

9'Thia-ergots

Novel cyclosporins having an -Allylgly- residue in the 2-position and/or a -(D)-Ser- residue in the 8-position and process for their production. The novel cyclosporins are useful as pharmaceuticals, e.g. as immunosuppressive and anti-inflammatory agents.

Growing community of inventors

Basel, Switzerland

Hans Kobel