Basf Aktiengesellschaft

Badische Anilin- & Soda-fabrik Aktiengesellschaft

Hans Kiefer

Johannes Grimmer

Heinz Hohenschutz

Hagen Jaedicke

Christoph Martin

Johannes E Schmidt

Max Strohmeyer

Joachim U Schneider

Wolfgang Bewert

Wolfgang Buehler

Ernst-Heinrich Pommer

Herbert Naarmann

Leopold Hupfer

Joachim Meyer

Paul Grafen

Ferdinand Lippert

Otto Hertel

Roland Betz

Lothar Arnold

Werner Reutemann

Manfred Herr

Fritz Fink

Dieter M Poralla

Hansjoerg Bipp

Konrad Rauch

Dieter Hesse

Gunter Eipper

Hans Osieka

In a process for preparing dry, free-flowing choline chloride-containing powders by atomizing an aqueous choline chloride solution, a colloid-free aqueous choline chloride solution is atomized in a countercurrent-flowing air stream that contains, finely dispersed, a hydrophobic spraying auxiliary metered in in such amounts that the sprayed choline chloride droplets are coated with 2 to 15% by weight of spraying auxiliary, based on choline chloride calculated as 100%, and the coated particles are, if desired, collected in a fluidized bed and dried in the gas stream.

Preparation of choline chloride-containing powders, these powders, and

Preparation of vitamin E

A process for preparing spray granules or microgranules, which contain no binder, are non-dusting and free-flowing, from finely divided pure riboflavin, comprises subjecting an aqueous or water-containing suspension of the pure finely divided riboflavin to

Spray granules or microgranules of pure riboflavin which contain no

A process for preparing formic acid by thermal cleavage of quaternary ammonium formates of the general formula I ##STR1## where R.sup.1, R.sup.2 and R.sup.3 are C.sub.1 - to C.sub.14 -alkyl, C.sub.3 - to C.sub.8 -cycloalkyl, aryl or C.sub.7 - to C.sub.16 -aralkyl, or together are 1,4- or 1,5-alkylene which is unsubstituted or substituted one to four times by C.sub.1 -to C.sub.4 -alkyl, with the proviso that the sum of the carbon atoms of R.sup.1, R.sup.2 and R.sup.3 in the quaternary ammonium formates I is 7 to 40, comprises carrying out the cleavage in the presence of secondary formamides of the general formula II ##STR2## where R.sup.4 and R.sup.5 are C.sub.2 - to C.sub.10 -alkyl, C.sub.3 - to C.sub.8 -cycloalkyl, aryl or C.sub.7 - to C.sub.16 -aralkyl, or together are 1,4- or 1,5-alkylene which is unsubstituted or substituted one to four times by C.sub.1 - to C.sub.4 -alkyl, which formamides boil 30.degree. to 150.degree. C. lower than the tertiary amine of the general formula III ##STR3## where R.sup.1, R.sup.2 and R.sup.3 have the abovementioned meanings, contained in the formate I.

Preparation of formic acid by thermal cleavage of quaternary ammonium

A method of purifying ferment-produced riboflavin, wherein the impure riboflavin is suspended in water or dilute aqueous acid, and the suspension is heated at a temperature of from 75.degree. to 130.degree. C. for from 0.3 to 3 hours with stirring, during which time crystal transformation takes place, after which the mixture is cooled and the purified product is isolated in known manner.

Method of purifying ferment-produced riboflavin

Anhydrous or substantially anhydrous formic acid is prepared by hydrolyzing methyl formate in the presence of a formamide and then obtaining the formic acid from the hydrolysis mixture by distillation, by a method in which the hydrolysis is carried out in the presence of 0.5-3 moles, per mole of methyl formate, of a water-soluble formamide of the general formula I ##STR1## where R.sup.1 and R.sup.2 are each alkyl or together form an alkylene group, giving a 5-membered to 7-membered ring, with the proviso that the sum of the carbon atoms in R.sup.1 and R.sup.2 is 5 or 6 and, in the case of an alkylene group, a carbon atom which is not directly bonded to the N atom can be replaced by an oxygen atom.

Preparation of formic acid

A process for the isolation of a carboxylic acid of the general formula (I)

Isolation of a carboxylic acid from an aqueous solution thereof

Powdered and/or granulated menadione sodium bisulfite formulations additionally contain a physiologically tolerated organic or inorganic acid. The novel formulations possess good water solubility and stability.

Stabilized menadione bisulfite formulations and their preparation

An improved process for preparing riboflavin 5'-phosphate (FMN) or its monosodium salt by reacting riboflavin with excess phosphorus oxychloride in a solvent, hydrolyzing of the resulting reaction mixture and, if desired, partially neutralizing with aqueous sodium hydroxide solution, comprises reacting the riboflavin with from 1.2 to 3 moles of phosphorus oxychloride per mole of riboflavin in a suitable lactone, especially .gamma.-butyrolactone, as solvent. The process is particularly advantageous when the reaction mixture is hydrolyzed at from 80.degree. to 90.degree. C. continuously or batchwise.

Preparation of riboflavin 5'-phosphate (FMN) and its sodium salt in a

Riboflavin-4',5'-cyclophosphoric acid chloride of the formula I ##STR1## its preparation by reacting an alkali metal salt of riboflavin, in an aprotic solvent, with phosphorus oxychloride, its use for the preparation of riboflavin-5'-phosphate and of the sodium salt of riboflavin-5'-phosphate, and a process for the preparation of riboflavin-5'-phosphate or its sodium salt via the novel phosphoric acid ester chloride.

Preparation of riboflavin-5'-phosphate (5'-FMN) and its sodium salt, and

Riboflavin produced by a microbial method is prepared in the form of free-flowing, non-dusting, spray-dried granules or microgranules as a feed additive by removing water from the mixture discharged from microbial fermentation for the preparation of riboflavin, wherein the mixture is subjected to

Preparation of riboflavin, produced by a microbial method, in the form

An animal feed or drinking water contains a biocidally or biostatically active amount of not less than one formic acid ester of 1,2-propanediol.

Animal feed or drinking water containing propanediol formates

A novel bisulfite adduct of menadione, the menadione choline bisulfite adduct, a process for its preparation, and its use as an antihemorrhagic agent.

Menadione choline bisulfite adduct, its preparation and antihemorrhagic

2-(N-Formylamino)-propionitrile is prepared by reacting acrylonitrile with formamide in the presence of a basic compound by a process in which the basic compound used is a tertiary nitrogen base.

Preparation of 2-(N-formylamino)-propionitrile

Ionones are prepared by cyclization of pseudoionone with concentrated sulfuric acid in the presence of an organic solvent or diluent, while cooling, and by dilution of the reaction mixture with water, by a continuous process in which the pseudoionone is combined with an aliphatic or cycloaliphatic hydrocarbon which boils at 25.degree.-65.degree. C. under the reaction conditions, or an aliphatic chlorohydrocarbon, and the sulfuric acid, with thorough mixing and evaporative cooling by partial or complete vaporization of the solvent present in the reaction mixture, combination being effected so that the temperature of the reaction mixture is from 25.degree. to 65.degree. C. and the residence time of this mixture before it is diluted with water is from 0.5 to 20, preferably from 0.1 to 5, seconds. The novel process can be used to prepare .alpha.- and .beta.-ionone in a technically simple and advantageous manner and in very good yields.

Growing community of inventors

Wachenheim, Germany

Hans Kiefer