Teva Pharmaceutical Industries Limited

Hans Jörg Kirner

Martin Studer

Gabriele Baisch

Reinhold Öhrlein

Frank Bienewald

Stephan Burkhardt

Synthesis methods for the preparation of intermediates which are suitable for the preparation of statin derivatives, and especially to synthesis methods for the intermediate of formula (VI) wherein R' and R&#x2032; are each independently of the other hydrogen or hydroxy-protecting group, or together are a bridging hydroxy-protecting group; and Ris a carboxy-protecting group. 

Process for the preparation of 7-amino syn 3,5-dihydroxy heptanoic acid derivatives, intermediates thereof and methods for their preparation

The invention relates to novel synthesis methods for the preparation of the intermediates, which are suitable for the preparation of statin derivatives, especially to novel synthesis methods of the intermediate of formula VI wherein R' and R&#x2032; are each independently of the other hydrogen or a hydroxy-protecting group or together are a bridging hydroxy-protecting group, and Ris a carboxy-protecting group, which methods are carried out by conversion of the intermediate of formula XVI wherein R&#x2032; and R&#x2032; are each independently of the other hydrogen or a hydroxy-protecting group, R* and R** are each independently of the other hydrogen or an amide-protecting group, and Ris a carboxy-protecting group; which methods proceed to further new intermediates and methods for their preparation 

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Pratteln, Switzerland

Hans Jörg Kirner