Synovo Gmbh

Other

C-a-i-r Biosciences Gmbh

Hans-Jurgen Gutke

Michael W Burnet

Jan-Hinrich Guse

Michael Wolff

Gene Kim

Georgia Tsotsou

Irina Droste-Borel

Albert Beck

Laurence Barker

Jeannette Reichert

Kattie Luyten

Maximilian Busch

Moussa Khobzaoui

Simona Margutti

Thomas Meindl

The invention features novel macrocyclic compounds, methods of making the compounds, pharmaceutical compositions including the compounds, and methods of treatment using the compounds.

Macrocyclic compounds pounds and methods of use thereof

This invention features a method of identifying a compound useful for enhancing efficacy of a therapeutic agent. The method includes incubating a compound in blood cells; separating immune cells from erythrocytic cells; and determining the ratio of the concentration of the compound in the immune cells to the concentration of the compound in the erythrocytic cells; wherein the compound comprises a transportophore and a therapeutic agent, in which the transportophore is covalently bonded to the therapeutic agent via a bond or a linker.

Method of identifying improved conjugates of biologically active compounds

Macrocyclic compounds and methods of use thereof

This invention features a compound of the following formula:T-(-L-C), T is a transportophore, L is a bond or a linker having a molecular weight up to 240 dalton, C is a non-antibiotic therapeutic agent, and m is 1, 2, 3, 4, 5, 6, 7, or 8, in which the transportophore has an immune selectivity ratio of at least 2, the transportophore is covalently bonded to the non-antibiotic therapeutic agent via the bond or the linker, and the compound has an immune selectivity ratio of at least 2.

Conjugates of biologically active compounds, methods for their preparation and use, formulation and pharmaceutical applications thereof

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Stuttgart, Germany

Hans-Jurgen Gutke