Goedecke Aktiengesellschaft

Warner-lambert Company

Hans-Jurgen Betche

Johannes Hartenstein

Hubert G Barth

Hartmut Osswald

Christoph Schachtele

Claus Rudolph

Reinhard Reck

Bruce D Roth

David Christopher Horwell

Bharat Kalidas Trivedi

Paul C Unangst

Martyn C Pritchard

Bradley Dean Tait

Edward Roberts

Reginald S Richardson

Ann Holmes

Michael D Mullican

Corinne E Augelli-Szafran

Julian Aranda

Uwe Trostmann

The present invention provides bis-(1H-indol-3-yl)maleinimide derivatives and the pharmacologically acceptable salts thereof, processes for the preparation of these compounds, and pharmaceutical compositions containing them for the treatment of heart and blood vessel diseases, such as thromboses, arteriosclerosis, hypertension, of inflammatory processes, allergies, cancer, and certain degenerative damages of the central nervous system, as well as of diseases of the immune system and viral diseases.

Bis-(1H-indol-3-yl)-maleinimide derivatives, processes for the

Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the

Novel unnatural dipeptoids useful as agents in the treatment of obesity, hypersecretion of gastric acid in the gut, gastrin-dependent tumors, or as antipsychotics are disclosed. Further, the compounds are antianxiety agents and antiulcer agents. The compounds are agents useful for preventing the response to withdrawal from chronic treatment or use of nicotine, diazepam, alcohol, cocaine, caffeine, and opioids. The compounds are also useful in treating and/or preventing panic attacks. Also disclosed are pharmaceutical compositions and methods of treatment using the dipeptoids as well as processes for preparing them and novel intermediates useful in their preparation. An additional feature of the invention is the use of the subject compounds to prepare diagnostic compositions.

Amino acid analogs as CCK antagonists

Growing community of inventors

Vorstetten, Germany

Hans-Jurgen Betche