Abbvie Biotechnology Ltd

Abbvie Inc.

Abbott Laboratories Corporation

Abbvie Deutschland Gmbh and Co Kg

Abbott Biotechnology Ltd.

Hans-Juergen Krause

Lisa Baust

Michael Dickes

Wolfgang Fraunhofer

Gerhard Winter

David Wayne Borhani

Stefan Gottschalk

Anette Koenigsdorfer

Markus Tschoepe

Annika Bartl

Katharina Kaleta

Michael Siedler

Peter K Lassner

Michael Adler

Geoffrey Lee

David W Borhani

The invention provides an aqueous formulation comprising water and a protein, and methods of making the same. The aqueous formulation of the invention may be a high protein formulation and/or may have low levels of conductity resulting from the low levels of ionic excipients. Also included in the invention are formulations comprising water and proteins having low osmolality.

Protein formulations and methods of making same

The invention provides an aqueous formulation comprising water and a protein, and methods of making the same. The aqueous formulation of the invention may be a high protein formulation and/or may have low levels of conductivity resulting from the low levels of ionic excipients. Also included in the invention are formulations comprising water and proteins having low osmolality.

A liquid aqueous pharmaceutical formulation is described which has a high protein concentration, a pH of between about 4 and about 8, and enhanced stability.

Formulation of human antibodies for treating TNF-alpha associated disorders

A method for preparing a protein or peptide powder is provided that includes spray drying a solution including more than, e.g., about 50 mg/mL of a protein or peptide (e.g., an antibody or antigen binding portion thereof), and at least one excipient. Also provided are stable powdered compositions including a protein and an excipient having less than, e.g., about 6% residual moisture.

Powdered protein compositions and methods of making same

Formulation of human antibodies for treating TNF-&#x3b1; associated disorders

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Gruenstadt, Germany

Hans-Juergen Krause