Eberhard-karls-universitat Tubingen

Eberhard-karls-universitaet Tuebingen Universitaetsklinikum

Hoechst Aktiengesellschaft

Eberhard-karls-universitat Tubinger

Eberhard-Karls-Universität Tuebingen Universitaetsklinikum

Eberhard-Karls-Universität Tübingen Universitaäsklinikum

Hans-Jorg Buhring

Reiner Lammers

Andrew Zannettino

Gunther Jung

Gundram Jung

Karl-Heinz Wiesmuller

Jorg Metzger

Paul J Simmons

Wichard Vogel

Sabrina Treml

Johannes Andreas Van Agthoven

David Jarossay

Irene Rappold

Suzanne M Watt

Venkata Lokesh Battula

Flavianna Cerabona

Gerhard Becker

Wolfgang Bessler

Sabrina Grimm

The present invention relates to the use of at least one antibody which binds to the SUSD2 antigen, or to functional fragments of the antibody, in combination with at least one of the following: an antibody which binds to CD140b, an antibody which binds to CD56, and/or an antibody which binds to TNAP, or functional fragments thereof, for isolation of mesenchymal stem cells, especially those having particularly chondrocytic and osteogenic differentiation potential. The invention further relates to processes for isolating such stem cells using these antibodies.

MSC surface marker

The present invention concerns antibodies produced from hybridoma cell lines chosen from the group comprising W8B2, W1C3, W7C6, W5C4, 24D2, 28D4, HEK-3D6, W4A5, W3D5, W5C5, 9A3G9, 58B1, F9-3C2F1, 39D5, for isolating and/or identifying homogenous mesenchymal stem cells. Furthermore a method is presented with which mesenchymal stem cells from adult primary tissue, for example bone marrow, can be identified and isolated with a high level of purity.

Method for isolating and/or identifying mesenchymal stem cells (MSC)

The invention relates to a monoclonal antibody, or fragments thereof, for isolating and/or identifying mesenchymal stem cells. In this connection, the antibody, or fragments thereof, bind to an antigen which is the same as that bound to by an antibody which is produced by the hybridoma cell line W8B2, which was deposited on 14.08.2002 in the DSMZ [German collection of microorganisms and cell cultures] under the number DSM ACC2567.

Monoclonal antibody W8B2 and method of use

The present invention relates to an antibody for the detection quantification, or isolation of basophils, mast cells, the precursor cells of basophils or mast cells, or a surface structure of basophils or mast cells. This antibody corresponds to an antibody with the designation 97A6, produced and released by hybridoma cells that were deposited in accordance with the Budapest Treaty on Feb. 12, 1997 under accession number DSM ACC 2297 at Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (DSMZ).

Method for binding basophils and mast cells

The invention relates to a monoclonal antibody specifically binding to the human FLT3/FLK2 receptor protein. The invention further relates to hybridoma cells producing such an antibody, as well as to a method for generation of such hybridoma cells. The monoclonal antibody is the antibody produced and released by hybridoma cells deposited under No. DSM 2249 at the German Collection of Microorganisms and Cell Cultures (DSMZ) and designated as 4G8B4B12.

Antibody 4G8B4B12

A monoclonal antibody specific to the cell surface glycoprotein CD164 is designated 67D2 and produced by hybridoma cells deposited under No. DSM ACC2303 at the German Collection of Microorganisms and Cell Cultures Ltd., DSMZ.

Antibody 67D2

According to certain embodiments, the invention relates to a method of producing antibodies employing an immunoconjugate produced by conjugating at least one membrane-anchoring compound with at least one partial sequence of a viral, bacterial, or protoral protein. The immunoconjugate has the advantage that it can be stored for a very long time even without cooling. According to certain embodiments, the invention relates to an immunoconjugate for the specific induction of cytotoxic T-lymphocytes which comprises a conjugate from at least one membrane anchor compound and a protein, containing at least one killer T-cell epitope, of a virus, a bacterium, a parasite or a tumor antigen, or at least one partial sequence containing at least one killer T-cell epitope of a viral, bacterial or parasite protein or of a tumor antigen.

Membrane anchor/active compound conjugate, its preparation and its uses

The present invention relates to a monoclonal antibody that binds specifically to a human stem cell factor (SCF) receptor. The invention further relates to hybridoma cells that produce such an antibody, and to a method for generating such hybridoma cells.

Stem cell factor receptor-(c-kit)-specific monoclonal antibody A3C6E2

The invention relates to a monoclonal antibody specifically binding to the human FLT3/FLK2 receptor protein. The invention further relates to hybridoma cells producing such an antibody, as well as to a method for generation of such hybridoma cells. One example of such a monoclonal antibody is the antibody produced and released by hybridoma cells deposited under No. DSM 2248 at the German Collection of Microorganisms and Cell Cultures (DSMZ).

Antibody BV10A4H2 specific for human FLT3/FLK2 receptor and mybridoma

An antibody against peanut agglutinin-(PNA)-binding glycoprotein on the surface of cells is named 103B2 and registered at the German Collection of Microorganisms and Cell Cultures GmbH, DSMZ, under the Budapest Treaty.

Growing community of inventors

Tubingen, Germany

Hans-Jorg Buhring