Hoffmann-la Roche Inc.

Other

Hans Johann Mayer

Michael J Klaus

Albert E Fischli

Erich Widmer

Walter Boguth

Alexander E Wick

Reinhard Zell

Hans G Leuenberger

Frank Kienzle

Werner Bollag

Pierre-Charles Wyss

Robert K Muller

The novel retinoids of the formula ##STR1## wherein R represents a residue of a sugar attached ester-wise or a residue of an amino-sugar attached amide-wise or of derivatives of such sugars and n is 1 or 2, can be used as medicaments, e.g. for the treatment of neoplasms, acne and psoriasis. These compounds are obtained by reacting a sugar or an aminosugar or a derivative thereof with a reactive derivative of 9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid, optionally followed by the modification of reactive groups present in the reaction product.

Retinoid carbohydrates

The compound 5[4(acyloxy or protected hydroxy-3-oxo-2,6,6-trimethyl-cyclohex-1-en-1-yl)-3-methyl-penta-1,4-dien- 3-ol], an intermediate for the coloring agent astaxanthin, its conversion to astaxanthin and its preparation from 4-oxo-.beta.-ionone including intermediates in this synthesis.

Process for producing astaxanthin

A process for fermentatively hydrogenating and reducing ketoisophorone to produce optically active [4R,6R]-4-hydroxy-2,6,6-trimethyl-cyclohexanone useful as an intermediate in the production of optically active carotenoids and intermediates in the production of these carotenoids.

Optically active cyclohexane derivatives

A process for preparing (3,4,5,6)-4-benzyloxymethyl-hexahydro-5-hydroxy-2H-cyclopenta[b]furan-2-on e, a known intermediate for producing prostaglandins from 5,6-dimethylbicyclo[2.2.1]hept-5-en-2-endo-3-endo-dicarboxylic acid anhydride and intermediates in this process.

4-Benzyloxymethyl-5-[(1-pyrrolidinyl-carbonyl)-methyl]-1,3-cyclopent

Process for synthesizing a prostaglandin from a hexahydro-4-(lower alkoxy)-2H-oxireno[3,4]cyclopenta[1,2-b]furan, utilizing as an intermediate in the process a hexahydro-5-hydroxy-2-lower alkoxy-2H-cyclopentab]furan-4-carboxaldehyde, and the novel cyclopenta(b)furan intermediates of the process.

Prostaglandin intermediates

Process for synthesizing a prostaglandin from a hexahydro-4-(lower alkoxy)-2H-oxireno [3,4] cyclopenta[1,2-b] furan, utilizing as an intermediate in the process a hexahydro-5-hydroxy-2-lower alkoxy-2H-cyclopenta [b]furan-4-carboxaldehyde, and the novel cyclopenta(b)furan intermediates of the process.

Hexahydro-5-oxy-2-loweralkoxy-2H-cyclopenta[b]-furan-4-carbonitrile

A novel process for the preparation of polyene compounds useful as coloring agents in foods, cosmetics, and pharmaceutical preparations. Novel polyenes are also disclosed. The present invention relates to polyene compounds. More particularly, the invention is concerned with novel carotenoid polyene compounds, derivatives thereof and a process for their manufacture.

Novel polyene compounds and process therefor

Process for synthesizing a prostaglandin from a hexahydro-4-(lower alkoxy)-2H-oxireno[3,4]cyclopenta[1,2-b]furan, utilizing as an intermediate in the process a hexahydro-5-hydroxy-2-lower alkoxy-2H-cyclopenta[b]furan-4-carboxyaldehyde, and the novel cyclopenta(b)furan intermediates of the process.

Hexahydro-cyclopentano[b]furans having a 2-C.tbd.C containing

Process for synthesizing a prostaglandin from a hexahydro-4-(lower alkoxy)-2H-oxireno[3,4]cyclopenta[1,2-b]furan, utilizing as an intermediate in the process a hexahydro-5-hydroxy-2-lower alkoxy-2H-cyclopenta[b]furan-4-carboxaldehyde, and the novel cyclopenta(b)furan intermediates of the process.

Growing community of inventors

Fullinsdorf, Switzerland

Hans Johann Mayer