Roche Diagnostics Operations, Inc.

Roche Diagnostics Gmbh

Hans-Joerg Pfleiderer

Ralf Gessler

Udo Hoss

Uwe Wittmann

Helmut Rinne

Hans-Ulrich Zieten

Rolf Fussgaenger

The invention concerns an array and a method for dosing a hormone regulating the blood glucose, especially insulin, of a diabetic patient. In order to improve the administration of the hormone, the invention provides the following characteristic combination: a first sensor for measuring tissue glucose level; a controller having as an input the measured tissue glucose level from the first sensor, the controller having a control algorithm to determine an amount of hormone to be dosed based upon the measured tissue glucose level; a hormone dosing unit connected to the controller and automatically administering a hormone dose based upon a signal received from the controller; a second sensor for measuring an influencing patient variable; a pilot control device connected to the second sensor, the pilot control device connected to and forming a circuit with the controller, the pilot control device acting on the controller in accordance with the influencing patient variable that is measured by the second sensor, whereby the pilot control device reduces dead time of the controller.

Array and method for dosing a hormone regulating blood sugar in a patient

The invention concerns an array and a method for dosing a hormone regulating the blood glucose, especially insulin of a diabetic patient (). In order to improve the administration of the hormone, the invention provides the following characteristic combination: a) a measuring device () to detect measured values correlatable with blood sugar; b) a controlling means () comprising a controller () and a hormone dosing device () for supplying a hormone dosage; c) a pilot control device () acting on the hormone fine dosage controlling means () for performing a coarse pre-control in accordance with at least one influence variable that influences blood glucose.

The invention concerns an arrangement for determining the concentration of glucose in a tissue fluid. In the microdialysis technology used for this purpose, perfusate-containing glucose is transported in intermittent delivery pulses through a microdialysis probe inserted into the tissue fluid and dialysate obtained in this process is passed to a measuring cell to record the glucose content. In order to achieve an exact determination of glucose even with a reduced dialysis period, it is proposed that the starting content of glucose in the perfusate is adapted to the glucose content of the tissue fluid by means of a control device in accordance with a command variable derived from the measurement signals of the measuring cell. When the control deviation is negligible the momentary starting content of glucose in the perfusate can be determined as a measure for the glucose content of the tissue fluid.

Device for determining a glucose concentration in a tissue fluid

The invention concerns a method and an arrangement for determining the concentration of glucose in a body fluid. In the microdialysis technology used for this purpose, perfusate containing glucose is transported in intermittent delivery pulses through a microdialysis probe () inserted into the body fluid and dialysate obtained in this process is passed to a measuring cell () to record the glucose content. In order to achieve an exact determination of glucose even with a reduced dialysis period, it is proposed that the starting content of glucose in the perfusate is adapted to the glucose content of the body fluid by means of a control device () in accordance with a command variable derived from the measurement signals of the measuring cell (). When the control deviation is negligible the momentary starting content of glucose in the perfusate can be determined as a measure for the glucose content of the body fluid.

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Ulm, Germany

Hans-Joerg Pfleiderer