Bayer Aktiengesellschaft

Creative Therapeutics Gmbh

Rainer Endermann

Karl G. Metzger

Ingo Haller

Andreas Krebs

Thomas Schenke

Klaus Grohe

Uwe Petersen

Michael Schriewer

Hans-Joachim Zeiler

Karl G Metzger

Peter Stadler

Michael Boberg

Rolf Angerbauer

Oswald Lockhoff

Bernd-Wieland Kruger

Klaus-Dieter Bremm

Klaus G Stunkel

Gunter Schmidt

Karl-Georg Metzger

Klaus Schaller

Dieter Habich

Wolfgang Hartwig

Eckart Voss

Gunter Benz

Delf Schmidt

Wilfried Schrock

Jorg Pfitzner

Hans-Georg Opitz

Arnold Paessens

Gunther Kinast

Hein-Peter Kroll

Gert Streissle

Helmut Brunner

Yutaka Hayauchi

Volker Klimetzek

Dieter Arlt

Thomas Himmler

Manfred Plempel

Hermann Hagemann

Engelbert Kuhle

Klaus Sasse

Franz Kunisch

Hans-Joachim Kabbe

Martin Scheer

Herbert Voege

Thomas Philipps

Paul Naab

Gerd Fengler

Klaus Groche

Klaus Crohe

Gunter E Hubner

Jurgen Dornhagen

Klaus Grobe

Peter Taylor

The invention is related to 7-amino-1-cyclopropyl-6,8-dihalogeno-1,4-dihydro-4-oxo-3-quinoline-carboxy lic acids of the formula (I) ##STR1## in which X.sup.1, X.sup.2, R.sup.1 and R.sup.2 have the meaning as pointed out in the following specification. Moreover, the invention is related to a process for the production of the compounds of formula (I) and to antibacterial agents containing them.

Intermediates for

Process for the preparation of antibacterial compounds of the formula ##STR1## comprises condensing an oxo compound of the formula ##STR2## with an amino compound of the formula ##STR3## to produce a compound of the formula ##STR4## reacting the compound of the formula (III) with a compound of the formula ##STR5## to give a compound of the formula ##STR6## and then eliminating the amino-protective group ##STR7##

Preparation of 7-(3-amino- and

7-(1-Pyrrolidinyl)-3-quinolone- and -naphthyridone-carboxylic acid derivatives as antibacterial agents and feed additives, of the formula ##STR1## in which X.sup.1 is halogen, X.sup.2 is hydrogen, halogen, amino or other radical, R.sup.1 is alkyl, cycloalkyl, optionally substituted phenyl or other radical, R.sup.2 is hydrogen, alkyl or a dioxolylmethyl radical, R.sup.3 is ##STR2## and A is N, CH, C-halogen, or the like, or forms a bridge with R.sup.1, and addition products thereof.

7-(1-pyrrolidinyl)-3-quinolone- and - naphthyridone-carboxylic acid

The invention is related to 7-amino-1-cyclopropyl-6,8- dihalogeno-1,4-dihydro-4-oxo-3-quinoline-carboxylic acids of the formula (I) ##STR1## in which X.sup.1, X.sup.2, R.sup.1 and R.sup.2 have the meaning as pointed out in the following specification. Moreover, the invention is related to a process for the production of the compounds of formula (I) and to antibacterial agents containing them.

7-amino-1-cyclopropyl-6,8-dihalogeno-

8-chloro-1-cyclopropyl-6,7-difluoro-1,

The invention relates to new 8-vinyl- and 8-ethinylquinolonecarboxylic acids, process for their preparation, and antibacterial agents and feed additives containing them.

8-vinyl- and 9-ethinyl-quinolone-carboxylic acids

The invention relates to new quinolone- and naphthyridonecarboxylic acid derivatives which are substituted in the 7-position by a partly hydrogenated isoindolinyl ring, processes for their preparation and antibacterial agents and feed additives containing these compounds.

7-isoindolinyl-quinolone-carboxylic acid derivatives

An antibacterially active quinolone or naphthyridonecarboxylic acid derivative of the formula ##STR1## in which R.sup.1 stands for various organic radical,

Quinolone- and naphthyridone carboxylic acid derivatives, process for

7-(1-Pyrrolidinyl)-3-quinolone- and -naphthyridonecarboxylic acid derivatives as antibacterial agents and feed additives, of the formula ##STR1## in which X.sup.1 is halogen,

7-(1-pyrrolidinyl)-3-quinolone carboxylic acid derivatives as

The invention relates to naphthyridonecarboxylic acid derivatives which are substituted in the 7-position by an optionally partially hydrogenated azaisoindolinyl ring, to processes for their preparation, and to antibacterial agents and feed additives containing them.

Naphthyridonecarboxylic acid derivatives

The invention relates to new quinolonecarboxylic acid derivatives which are substituted in the 7-position by an optionally partially hydrogenated azaisoindolinyl ring, to processes for their preparation, and to antibacterial agents and feed additives containing them.

7-azaisoindolinyl-quinolone-carboxylic acid derivatives

The invention relates to new 7-(2,7-Diazabicyclo[3.3.0]octyl)-3-quinolone- and -naphthyridonecarboxylic acid derivatives, processes for their preparation, and anti-bacterial agents and feed additives containing them.

7-(2,7-diazabicyclo[3.3.0]octyl)-3-quinolone-and-naphthyridonecarboxylic

Quinolone- and naphthridone carboxylic acid derivatives, process for

Antibacterial 5-alkylquinolonecarboxylic acids of the formula ##STR1## in which R.sup.3 is C.sub.1 -C.sub.4 - alkyl,

Antibacterial 5-alkylquinolonecarboxylic acids

Growing community of inventors

Velbert, Germany

Hans-Joachim Zeiler