Bayer Aktiengesellschaft

Hans-Joachim Kabbe

Arno Widdig

Peter Roessler

Rudiger Sitt

Andreas Knorr

Uwe Petersen

Hans-Peter Krause

Paul-Ernst Frohberger

Ulrich Niewohner

Eckhard Schwenner

Thomas M Aune

Gaetan Ladouceur

Wilhelm Stendel

Erich Klauke

Stanislav Kazda

Peter Stadler

Bernward Garthoff

Eckart Voss

Karl Heinrich Mayer

Hinrich Otten

Wilhelm Brandes

Karl G Metzger

Elisabeth Perzborn

Hans-Joachim Zeiler

Folker Lieb

Kurt Stoepel

Wilfried Paulus

Valentino J Stella

Friedel Seuter

Martin Scheer

Claudia Hirth-Dietrich

Hermann Oediger

Heinz Ziemann

Karl-Georg Metzger

Helmut Heitzer

Mithat Mardin

Ulrich Benz

Hans P Krause

Dieter Vor Der Bruck

Hans-Jurgen Rosslenbroich

Walter Gauss

Siegfried Petersen

Robert Bierling

Heiner Eckert

Ivar Ugi

Andrea Mayer

Annedore Mayer

Hildegard E Mayer

Ghanem Atassi

Laman A Al-Razzak

N,N-Disubstitued piperazines are prepared by reacting either the appropriately substituted furans or the N-unsubstituted pyrrolidines with aminoalkylpiperazines. The substances according to the invention can be employed as active agents in medicaments, in particular for the production of immunomodulators.

N,N-disubstituted piperazines

Substituted pyrroloanthracenes are prepared by reacting either furanoanthracenes or N-unsubstituted pyrroloanthracenes with appropriately substituted alkylamines. The compounds can be employed as active ingredients in medicaments, in particular as immunomodulators.

Substituted pyrroloanthracenes and -diones

The piperazine-substituted pyrroloanthracenes are prepared by reacting either furanoanthracenes with piperazinalkylamines or reacting unsubstituted pyrroloanthracenes first with dihalogenoalkyl compounds and then with appropriately substituted piperazines or by reacting furan derivatives first with piperazinalkylamines and then condensing with anthracenes. The new compounds can be employed as active ingredients in medicaments, in particular in immunomodulators.

Piperazine-substituted pyrroloanthracenes

The present invention relates to new substituted benzoxazepines and benzothiazepines of the general formula I ##STR1## in which X, R.sup.1, R.sup.2 and R.sup.3 have the meaning given in the description, processes for their preparation and their use in medicaments having vaso- and muscle-relaxing properties, in particular as circulatory agents.

Substituted benzoxazepines and benzothiazepines

Therapeutic compositions comprising the new derivatives of aminooxodihydroisoindolo-quinazoline of the formula ##STR1## are useful in inhibiting the growth of colon and rectal tumors.

Aminooxodihydroisoindoloquinazoline carcinostatic agents

A carcinostatic composition useful in inhibiting the growth of colon and/or rectal tumors comprising 8-amino-12-oxo-10, 12-dihydroindolo [1,2-b]-quinazoline of the formula: ##STR1##

Carcinostatic agent

Substituted benzopyrans of the formula ##STR1## in which --A-- is a single or double bond,

Substituted aminomethyl benzopyrans having anti-hypertensive activities

Novel substituted 4-hydroxy-benzopyrans of the formula ##STR1## in which X is a single bond, ##STR2## and the other radicals can have various meanings, or pharmaceutically acceptable addition salts thereof, which are active on the circulation system.

Circulation active novel substituted 4-hydroxy-benzopyrans

2-(1H-pyrazol-1-yl)-4-(3H)-quinazolinones of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are identical or different and denote hydrogen, halogen, alkyl, alkoxy, hydroxyl or amino and

Microbicidal agents containing 2-(1H-pyrazol-1-yl)-4-(3H)-quinazolinones

Norbornane- and norbornene-carboxylic acid amides of the formula ##STR1## in which ##STR2## represents the part structure ##STR3## A represents a ##STR4## or --CH.sub.2 --CH.sub.2 -- group, R.sup.1 and R.sup.2 each independently is hydrogen or an alkyl radical with 1-6 carbon atoms,

Novel norbornane- and norbornene-carboxylic acid amides thromboxan

The invention relates to alkylurea derivatives of Formula (I), as defined in the specification, which alkylurea derivatives are useful as hypolipaemic agents. Also included in the invention are methods for the manufacture of said alkylurea derivatives compositions and medicaments containing said alkylurea derivatives and methods for the use of said alkylurea derivatives.

Lipid absorption-inhibiting agents and their use

The invention relates to substituted 4-aminomethylene-chromans and chromens of Formula (I) infra, as well as methods for making of said chromans and chromens, compositions containing said chromans and chromens and methods for the use of said chromans, chromens and compositions containing said chromans and chromens. The compounds and compositions of the invention are useful for their circulation influencing activity.

Substituted 4-aminomethylene-chromans and -chromenes, processes for

Bisindolyl alkylene ureas lipid absorption-inhibiting agents and their

Chroman-4-ones are prepared by reacting an o-hydroxyarylcarbonyl compound with a carbonyl compound in the presence of an amine. A typical reaction of o-hydroxy-acetophenone with cyclopentanone can be depicted as follows: ##STR1##

Chroman-4-ones and process for preparing same

Lipid absorption-inhibiting 1,4-benzothiazines

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Leverkusen, Germany

Hans-Joachim Kabbe