Synthon B.v.

Synthon IP Inc.

Synthon Bct Technologies, LLC

Hans Jan Hoorn

Theodorus H A Peters

Jacobus Maria Lemmens

Jaroslav Pis

Radim Scigel

Frantisek Picha

Gerrit J B Ettema

Karel Pospisilik

Theodorus Hendricus Antonius Peters

Optically impure tamsulosin including racemic tamsulosin can be resolved into optically pure (R)- or (S)-tamsulosin by the use of diastereomeric sulfonate salts of tamsulosin in a fractional crystallization technique. Racemic tamsulosin free base is a useful starting material for the resolution process and a method of obtaining the same in solid form, including two crystalline polymorphic forms, is also provided.

Process for resolution of tamsulosin and compounds, compositions, and processes associated therewith

Amlodipine besylate forms are described, including amlodipine besylate hydrates and novel amlodipine besylate anhydrates. A method of making various amlodipine besylate forms from an aqueous medium as well as the use of the same as a calcium channel blocker are described.

Amlodipine salt forms and processes for preparing them

A new process to obtain pramipexole and related products is described. The process involves the reaction of new compounds of formula (6), wherein R is hydrogen or acyl group, R and R are either the same and each of them represents an alkoxy group of 1-4 carbons or they together form a C -C alkylenedioxy group or an oxo-group, with an alkylamine in the presence of a reducing agent or a hydrogen gas with hydrogenation catalyst. A process to obtain new compounds of formula (6) is also described.

Process for preparation of 2-amino-6 (alkyl) amino-4,5,6,7-tetrahydrobenzothiazoles

A compound or composition comprising N-formyl paroxetine of formula (1) is useful as a pharmaceutical and as a synthetic intermediate. The N-formyl paroxetine can be an impurity in paroxetine substances and methods of assaying for such an impurity are also useful.

N-formyl derivatives of paroxetine

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Nijmegen, Netherlands

Hans Jan Hoorn