Aktiebolaget Leo

Hans Jacob Fex

Bertil Hogberg

Torsten Rune Perklev

Sten Gunnar Veige

Bo Fredholm

Imre Konyves

Anders Robert Stamvik

Knut Bertil Hogberg

Krister A Holmberg

Sten K Kristensson

Bertil Hansen

B Goran Fredholm

This invention relates to novel 17.alpha.-esters of gestogens having an antitumour activity and to the preparation thereof. The invention is also concerned with pharmaceutical compositions containing the said compounds, and method of treatment therewith.

Novel 17-esters of 17.alpha.-hydroxy gestogens, compositions containing

This invention relates to novel enol esters of steroids having an antitumor activity and to the preparation thereof. The invention is also concerned with pharmaceutical compositions containing the said compounds and methods of treatment therewith.

Novel enol esters of steroids, compositions containing such compounds,

This invention relates to a novel carbamoylation method for the preparation of steroid phenolic N-disubstituted carbamate esters, and novel compounds in said method. Phenolic carbamate esters are useful for various purposes, for instance as pharmaceuticals, e.g. antitumor agents, as biocides, e.g. pesticides, and intermediates for preparing such useful compounds.

Acylation process for the preparation of steroid phenolic

This invention relates to a novel carbamoylation method for the preparation of phenolic N-disubstituted carbamate esters, and novel compounds in said method. Phenolic carbamate esters are useful for various purposes, for instance as pharmaceuticals, e.g. antitumor agents, as biocides, e.g. pesticides, and intermediates for preparing such useful compounds.

Acylation process for the preparation of phenolic N-disubstituted

This invention relates to novel secondary phosphoric acid esters and salts thereof, having valuable pharmacological properties, and to the preparation thereof. The invention is also concerned with pharmaceutical compositions containing the said compounds, and methods of treatment therewith. The esters are i.a. useful as selective inhibitors of prostaglandins and of Slow Reacting Substances (SRS). They also inhibit the formation of adenosine 3',5'-monophosphate (cyclic AMP). In addition the esters of this invention also exert intrinsic smooth muscle stimulatory activity.

Novel compounds, compositions containing such compounds, processes for

Method, composition and compounds for treating excess prostaglandins

New 21-esters of corticoid steroid hormones, the esters having an antitumor activity, are prepared by reacting a reactive derivative of the general formula ##STR1## wherein R.sup.1 can be hydrogen, lower alkyl, halogen, or lower alkoxy, X can be oxygen, sulphur, or a monovalent carbon-to-carbon bond, A can be alkylene, aminoalkylene, or lower-alkanoyl aminoalkylene, and A together with X also can be a monovalent carbon-to-carbon bond, with a corticoid steroid.

Cortical steroid nitrogen mustard compositions and treatment therewith

Secondary phosphoric acid esters, composition and method of use

Novel symmetrical secondary phosphoric acid esters having the general formula ##SPC1## Wherein the substituent R is positioned in meta or para position relative to the phosphoric acid ester group; processes for the preparation of said esters; and compositions containing said esters. The esters are i.a. useful as selective inhibitors of prostaglandins and compounds with prostaglandin activities. They also selectively antagonize the slow reacting substance (SRS).

Medicinal compositions and methods of use involving phosphoric acid

This invention relates to novel secondary phosphoric acid esters and salts thereof, having valuable pharmacological properties, and to the preparation thereof. The invention is also concerned with pharmaceutical compositions containing the said compounds, and methods of treatment therewith. The esters are i.a. useful as selective inhibitors of prostaglandins and of Slow Reacting Substances (SRS). They also inhibit the formation of adenosine 3' ,5'-monophosphate (cyclic AMP). In addition the esters of this invention also exert intrinsic smooth muscle stimulatory activity.

Secondary phosphoric acid esters

This invention relates to novel N-halogenoalkyl-N-nitroso carbamates and N.sup.4 halogenalkyl-N.sup.4 -nitroso allophanates of steroid compounds, having an anti-tumor activity, and to the preparation thereof. The invention is also concerned with pharmaceutical compositions containing the said compounds, and methods of treatment therewith.

Growing community of inventors

Helsingborg, Sweden

Hans Jacob Fex