Vrije Universiteit Brussel

Hans Ingelberts

Maarten Kuijk

Cedric Baijot

Cédric Baijot

A detection system for detecting fluorescence lifetime includes an excitation light source configured for repeatedly generating pulsed excitation light, and a detector. The detector has a single-photon detection circuit; a pulse-inhibit circuit for rejecting detected photons that occur outside each one of a series of measurement time windows, each subsequent measurement time window starting after a subsequent excitation light pulse has stopped, and stopping before a next excitation light pulse is generated, each measurement time window having a measurement window period; and a switched-capacitor circuit having an input terminal for receiving a voltage ramp signal that is restarted with each new measurement window period. The switched-capacitor circuit is configured for repetitively computing an average voltage. The switched-capacitor circuit has a node for outputting the computed average voltage as a measure of the fluorescence lifetime.

Circuit and method for fluorescence lifetime imaging

A detector device for detection of electromagnetic radiation impinging on a substrate and generating pairs of majority and minority charge carriers in the substrate, comprises at least one minority charge detection structure for, in a first mode, injecting a majority current so as to create an electric field for directing minority charge carriers towards the at least one minority charge detection structure for detecting minority charge carriers generated in the substrate; two or more minority charge removal structures per minority charge detection structure for, in a second mode, injecting a majority current so as to create an electric field, for draining minority charge carriers towards the two or more minority charge removal structures, away from the associated charge detection structure; and at least one substrate majority charge current sink for extracting the injected majority current.

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Hans Ingelberts