Hermes Pharma Gmbh

Hermes Arzneimittel Gmbh

Hans Höbart

Johannes Bartholomäus

Thomas Schweitzer

Gerd Weiss

Klaus Dandl

Wolfgang Schiemenz

Claudia Lang

Verena Garsuch

The invention provides a method for the preparation of effervescent granules wherein the reactive, effervescent components (one acidic and one alkaline CO-generating component) are brought to reaction with one another under stirring in a vacuum (100-900 mbar) in an evacuable mixing chamber, with said mixing chamber being evacuated to a first vacuum value p, and then 're-evacuated' to said first vacuum value pagain, optionally repeatedly, once the pressure has increased to a second vacuum value pdue to the progressing COformation of the effervescent reaction. The method is carried out in such a way that during at least the effervescent reaction step(s) the stirring speed in the mixing chamber exhibits a Froude number (Fr) of 0.5 or higher, preferably 0.8 or higher, more preferably 0.9 or higher; such as, in the range of 0.50 to 8.00, or 0.80 to 8.00, or 0.90 to 8.00.

Method for preparation of effervescent granules

Growing community of inventors

Pullach, Germany

Hans Höbart