Roche Diagnostics Operations, Inc.

Roche Diagnostics Gmbh

Hitachi-High-Technologies Corporation

F. Hoffmann-La Roche Ag

Hans Hornauer

Johann Karl

Helmut Lenz

Peter Sluka

Takenori Okusa

Yoichi Aruga

Alfons Nichtl

Kurt Weindel

Hironobu Yamakawa

Kenichi Takahashi

Friedemann Krause

Albert Geiger

Hans-Juergen Mueller

Wolfgang Mutter

Johann Berger

Peter Finckh

An automatic chemical analyzer in which a reaction solution is stirred by air ejected from an air ejection hole placed above a reaction container. The reaction region can be washed and cleaned sufficiently without causing damage, such as exfoliation of a coating reagent. A reaction container diskis provided with a poreand a pressure detectorconnected with the pore. Before and after the stirring operation, the ejection hole (nozzle)ejecting air is moved and the output value of the pressure detector is compared with a previously measured normal value. With a discharge pipeand a suction pipeinserted to the opening of the reaction containerto be close to both ends of the opening and the side wall of the container, the reaction regionat the bottom of the container is washed by continuous discharge and suction of cleaning fluid.

Chemical analyzer

The present invention relates to a method of producing a fluorescent polypeptide complex characterized in that an isolated fluorescent polypeptide is inter-molecularly cross-linked with itself or one or more other polypeptides and wherein said complex is of 40 nm to 500 nm in size, it also relates to a complex obtainable by such method, to conjugates comprising such a fluorescent polypeptide complex and to the use of such complex or conjugate.

Fluorescent polypeptide complex

The invention concerns a process for producing reagent carriers having a binding capability that are suitable for determining analytes in liquids, wherein the process comprises at least one step of treating a respective reagent carrier body in particular by transferring material between a treatment device and the reagent carrier body in a preparation device and wherein this treatment step takes place on the moving reagent carrier body during its transport in the preparation device or during a movement of the treatment device relative to the reagent carrier body in the preparation device.

Process and device for producing reagent carriers

The use of polyalkylene oxide modified reagents is disclosed in a method for the detection of an analyte or in suitable reagent kits for such methods.

Polyethylene glycol-derivatized biomolecules and their use in heterogeneous detection methods

A solid phase with at least one test area is described which contains reagents for the detection of at least one analyte in a sample, wherein the solid phase additionally comprises at least one control area for the detection of interfering reactions.

Use of check surfaces for identifying disturbing samples in a detection procedure

The present invention concerns a method for the detection of an analyte in a sample liquid by luminescence measurement according to the principle of a ligand-receptor assay, e.g. an immunoassay or a hybridization assay or a combination thereof, wherein a sample liquid is incubated with at least one receptor which carries a luminescent label and the presence or/and the amount of the analyte to be detected is determined in the sample liquid by measuring the luminescence in a measuring medium containing dispersed components.

White trigger preparations for improving the signal detection in bioluminescent and chemiluminescent reactions

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Peissenberg, Germany

Hans Hornauer