Sandoz Gmbh

Novartis Ag

Hans Hofmann

Rene P Traber

Michael Mutz

Thomas Schupp

Eugen Harri

Marion Mahnke

Klaus Memmert

Frank Petersen

Max Kuhn

Ernst K&uuml;sters

Roland M Wenger

Hans Kobel

Hans Tscherter

Michael Morris Dreyfuss

Kuhn Max

Roy Ewald

The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as well as aspects related thereto. New crystal forms of epothilone B are also described.

Fermentative preparation process for and crystal forms of cytostatics

The compound of formula I ##STR1## known as S 39163/F-I which is effective e.g. as an antimicrobial and against herpes viruses.

Antibiotic lactone compound

Cyclosporins wherein the amino acid residue at the 8-position is a (D)-acyloxy-.alpha.-amino acid residue, typically of formula ##STR1## wherein X=-MeBmt- or -dihydro-MeBmt-, Y=-.alpha.Abu-, -Ala-, -Thr-, -Val- or -Nva-, Z=-Val- or -Nva- and Q=R.sub.1 --CO--O--CH(R.sub.2)--CH(CO--)--NH--wherein R.sub.1 =H, C.sub.1-4 alkyl or phenyl and R.sub.2 =H or CH.sub.3, possess immunosuppressive, anti-inflammatory and anti-parasitic activity.

Novel cyclosporins

The present invention relates to cyclosporin derivatives, especially compounds of formula I ##STR1## wherein A is ##STR2## useful as anti-arthritic agents.

Process for producing cyclosporin derivatives

Compounds of formula I ##STR1## selected from the group consisting of cyclosporin G, wherein A is ##STR2## dihydrocyclosporin G, wherein A is ##STR3## and isocyclosporin G, wherein A is ##STR4## are useful in treating inflammations and arthritis and as immuno-suppressant agents.

Cyclosporin derivatives, their production and pharmaceutical

Organic compounds

Growing community of inventors

Ettingen, Switzerland

Hans Hofmann