Bausch-Lomb Incorporated

Hans Hoerauf

Erhard Kemnitz

Dirk-Henning Menz

Udo Gross

Joachim Dresp

Karin Kobuch

Dirk Henning Menz

The invention includes a method for the passivation of the surface of an intraocular lens, wherein the surface includes Br&#xf6;nsted sites. The intraocular lens is dipped into a solution of a fluoroalkyl silane having the general formula: R&#x2014;(CH)&#x2014;Si&#x2014;(O&#x2014;R). The residue R is selected from the group of H, CH, CHand CHand the fluoroalkyl residue Ris selected from the series CF(CF), with m=3 to 11 and n=0 to 4. The Br&#xf6;nsted sites on the surface are thereby deactivated by formation of Si&#x2014;Q&#x2014;bonds.

Method for the passivation of an intraocular lens

The invention relates to the utilization of a highly fluorinated oligomeric alkane as a therapeutic agent in ophthalmology, the alkane having the general formula [&#x2014;R(CH)CR&#x2014;CR&#x2014;], wherein Ris a linear or branched perfluorinated alkyl chain CFto CF, Rand Rare independently selected from the group consisting of H, CH, CHand CH, n is selected from the numbers 0, 1 and 2, and x is a number between 2 and 6, with a molar mass of at least 750. According to the invention, a pharmacological agent is provided that is used in ophthalmology and that causes little or no damage to the retina even when used over a long period.

Utilization of a highly fluorinated oligomeric alkane in ophthalmology

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Sierksdorf, Germany

Hans Hoerauf