Cis Pharma Ag

Joh a. Benckiser, Gmbh

Amics Ag

Joh. a. Benskiser Gmbh

Chemisches Instutut Schaefer Ag

Chemisches Institut Schaefer Ag

Hans Hitz

Heinrich Baust

Wolfgang Gross

Rolf Schäfer

Rolf Schaefer

Rolf Schafer

Christoph Schäfer

Christoph Schaefer

The invention relates to highly biocompatible or biophilic un-cross-linked or cross-linked polymers comprising one or more side-chain active acrylic amino acids of formula I wherein: X is &#x2014;NH(CH)&#x2014;, &#x2014;O&#x2014;CH&#x2014;CH&#x2014;, &#x2014;OCH&#x2014;, &#x2014;O&#x2014;CH(CH)&#x2014;, &#x2014;S&#x2014;CH&#x2014;, &#x2014;O-proline, and R is H or CH; and wherein the polymer further includes a free radical initiator and, optionally, a cross-linking agent having a plurality of polymerizable ethylenically unsaturated groups. The invention further concerns various highly biocompatible, cross-linked co-polymers comprising one or more monomers of formula I, and one or more other polymerizable monomers. Uses of such polymers and co-polymers for the production of contact lenses, intraocular lenses, implants, wound healing slabs, additives for food and cosmetics, conductive plastics, spinnable fibers, and the like are disclosed.

Biocompatible polymers and co-polymers, and uses thereof

The subject invention relates to a method of preparing a biocompatible polymer comprising epsilon-linked L-lysine having free alpha-amino and carboxy functions. The invention further encompasses the resulting biocompatible polymer and articles made from the polymer, in particular contact and intraocular lenses.

Methods for the preparation of biocompatible polymers, the polymers and their uses

The present invention provides a process for preparing polycarboxylic acid imidazolines of the general formula: ##STR1## wherein X is --Cl, --OH, --O--SO.sub.3 H, --O--PO.sub.3 H.sub.2, --O--CH.sub.2 --CH.sub.2 --COOH, --NH.sub.2, --NHalk or --N(alk).sub.2, alk being an alkyl radical containing up to 6 carbon atoms, n is a whole number of from 2 to 4, R is a C.sub.8 -C.sub.18 hydrocarbon radical which is straight-chained, branched, saturated or one to three times unsaturated, m is a whole number of from 2 to 5, R' is a hydrogen atom or a carboxyl group and R' is a hydrogen atom or a methyl radical. In the process, a compound of the formula ##STR2## in which R, X and n are as defined above, is condensed with about a 2- to 5-fold excess of acrylic acid, methacrylic acid, maleic acid or a mixture thereof.

Process for preparing polycarboxylic acid imidazolines by condensation

The present invention provides polycarboxylic acid imidazolines of the general formula: ##STR1## wherein X is --Cl, --OH, --O--SO.sub.3 H, --O--PO.sub.3 H.sub.2, --O--CH.sub.2 --CH.sub.2 --COOH, --NH.sub.2, --NHalk or --N(alk).sub.2, alk being an alkyl radical containing up to 6 carbon atoms, n is a whole number of from 2 to 4, R is a C.sub.8 -C.sub.18 hydrocarbon radical which is straight-chained, branched, saturated or one to three times unsaturated, m is a whole number of from 2 to 5, R' is a hydrogen atom or a carboxyl group and R' is a hydrogen atom or a methyl radical. The present invention also provides a process for the preparation of these compounds and cleaning agents containing them.

Polycarboxylic acid imidazolines, process for the preparation thereof

From organs of embryonic mammalia a new extract of active ingredients is recovered which extract can be used for controlling a reduced blood flow through periperhic organs and through the brain and which extract can be also used for controlling acne vulgaris. The corresponding extracts are used as active ingredients of corresponding pharmaceutical preparations. The new pharmaceutically active extract is prepared according to a process in which polar substances having a molecular weight below 5000 are isolated from the embryonic mammalian organs avoiding any degradation of substances having a higher molecular weight. The finely divided embryonic mammalian organs are extracted with a mixture of water and a water soluble organic solvent which contains nor more than 30 vol.-% of water at an about neutral pH value for stirring and refluxing. The resulting solution is then submitted to a predetermined sequence of further drying steps, heating steps and cooling steps, and finally to a filtration with an ultramembrane filter in order to remove any substances having a molecular weight of about 5000. The extract is then finally concentrated under vacuum to yield a liquid concentrate or a dry residue.

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Arisdorf, Switzerland

Hans Hitz