Alk-abello A/s

Hans-Henrik Ipsen

Henrik Hugo Jacobi

Lise Lund Mærkedahl

Tine Charlotte Beck

Soren Bogestrand

Niels Johansen

Gitte Lund

Peter Adler Würtzen

Morten Jonas Maltesen

Rasmus Linnemann Krogh

Maria Mercedes Ferreras Goméz

Merete Stavnsbjerg

Helene Henmar

Rikke Morkeberg

Jens Brimnes

R Ikke Morkeberg

Kaare Lund

Gitte Nordskov Hansen

Rafael Ignacio Monsalve Clemente

Maria Mercedes Ferreras Gómez

The invention relates to a method of measuring the immunological activity of a vaccine preparation in the form of a mixture of one or more allergenic enzyme(s) and an oxygen-containing metal salt adjuvant, wherein the mixture comprises a liquid phase and a solid phase, and wherein at least a part of the allergenic enzyme(s) is adsorbed to the solid phase, the method comprising the steps of measuring the enzymatic activity of the mixture in an enzyme activity assay, and using the measurement obtained as an indication of the immunological activity of the vaccine preparation, or using the measurement obtained for quantifying the amount of allergenic enzyme.

Method of measuring enzymatic activity of adsorbed allergenic enzyme

The present invention relates to a process for producing an allergen extract from a biological allergen source material comprising the steps of

Process for producing an allergen extract

The invention relates to an in vitro method of evaluating the immunological activity of a vaccine preparation in the form of a mixture of a molecular antigen and a carrier, wherein the mixture comprises a liquid phase and a solid phase, to which at least a part of the antigen is attached, the method comprising the steps of

Method of evaluating the immunological activity of a vaccine

The invention relates to a method of evaluating the immunological status of a subject comprising the steps of 1) determining the content of an antibody in a liquid sample from the subject using an immunoassay, wherein the reaction between the antibody of the sample and a ligand in the form of an antigen, an antibody or a hapten, the ligand being directed to the Fab region of the sample antibody, is carried out in the presence of other constituents of the sample to obtain a measurement2) determining the content of an antibody in the liquid sample using an immunoassay, wherein the reaction between the antibody of the sample and a ligand in the form of an antigen, an antibody or a hapten, the ligand being directed to the Fab region of the sample antibody, is carried out in the absence of other constituents of the sample to obtain a measurementand 3) interrelating measurementsandto express the interference and using the interference as a parameter for evaluating the immunological status of the subject.

Method of detecting an antibody in a liquid sample

The invention relates to a method of evaluating the immunological status of a subject comprising the steps of 1) determining the content of an antibody in a liquid sample from the subject using an immunoassay, wherein the reaction between the antibody of the sample and a ligand in the form of an antigen, an antibody or a hapten, the ligand being directed to the Fab region of the sample antibody, is carried out in the presence of other constituents of the sample to obtain a measurement , 2) determining the content of an antibody in the liquid sample using an immunoassay, wherein the reaction between the antibody of the sample and a ligand in the form of an antigen, an antibody or a hapten, the ligand being directed to the Fab region of the sample antibody, is carried out in the absence of other constituents of the sample to obtain a measurement , and 3) interrelating measurements and to express the interference and using the interference as a parameter for evaluating the immunological status of the subject.

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Hillrod, Denmark

Hans-Henrik Ipsen