Knoll Aktiengesellschaft

Hans-Heinrich Gruenhagen

Joerg Rosenberg

Cynthia A Romerdahl

Dieter Lenke

Gerda Von Philipsborn

Juergen Heberger

Egon Brode

A process for producing solutions of active substances of low solubility, which comprises (1) dissolving the active substance with a phospholipid and a water-soluble lipid in an organic solvent, (2) evaporating the resulting solution to dryness, (3) taking up the residue in a strongly acidic buffer and stirring at elevated temperature until a colloidal solution is produced, (4) cooling the colloidal solution and adjusting to a pH of 6-7 and sterilizing. Particularly suitable for the process are lipids of the formula ##STR1## wherein m, a, b, x and y have the meanings indicated in the description.

Preparation of colloidal aqueous solutions of active substances of low

.alpha.-Aminocarboxylic acid derivatives of the formula: ##STR1## where n, X, Y and Z have the meanings stated in the description, and their preparation are described. The compounds are used in a method for improving delivery and reducing toxicity of biologically active substances by encapsulation of the biologically active substance with the above compounds.

Method for improving delivery and reducing toxicity of biologically

Hydroxypropafenone glycerides of the formula I ##STR1## where R is n-propyl or 1,1-dimethylpropyl,

Growing community of inventors

Ludwigshafen, Germany

Hans-Heinrich Gruenhagen