Novartis Ag

Novartis Pharma Gmbh

Hans-Günter Zerwes

Gebhard Thoma

Markus Streiff

Fraser Glickman

Rainer Albert

Nigel Graham Cooke

Ian Lewis

Gisbert Weckbecker

Christian Bruns

Walter Schuler

Rolf Baenteli

Jiri Kovarik

François Nuninger

Johannes Schuurmann Hessel

The invention relates to isothiourea derivatives of formula I: wherein Ris a residue of one of the following structures: where the variables are as defined in the claims of the invention, as well as processes for production of these compounds.

Isothiourea derivatives of imadazo[2,1-b]Thiazoles and 5,6-dihydro derivatives thereof useful as CXCR4 chemokine receptor inhibitors

Disclosed are ergoline derivatives, Formula (I), wherein either each of Rand R, independently, is H; optionally Rand/or R-substituted-phenyl or -phenyl-Calkyl; optionally Rand/or R-substituted-heteroaryl or -heteroaryl-Calkyl; optionally Rand/or R-substituted heteroaryl N-oxide; optionally R-substituted C-Calkyl; optionally R-substituted C-Calkenyl, optionally R-substituted C-Calkynyl; optionally R-substituted C-Ccycloalkyl, or optionally R-substituted C-Ccycloalkenyl; or Rand Rform together with the nitrogen atom to which they are attached an optionally R-substituted 3-8 membered ring containing in addition to the nitrogen atom up to 2 heteroatoms selected independently from N, O and S; Ris H; OR; CHRR; (CH)NRR; CH&#x2014;CH&#x2014;OR; CH&#x2014;CO&#x2014;NRR; or CO&#x2014;CHRR; Ris F; Cl; Br; I; OR; NRRor has one of the significances given for R; and Rhas one of the significances given for R, in free form or in salt form for preventing or treating disorders or diseases mediated by interactions between chemokine receptors and their ligands. 

Ergoline derivatives

Disclosed are compounds of formula I: wherein R, R, Rand X are as defined herein, in free or salt form, which are useful as CCR5 inhibitors, e.g. in the prevention or treatment of disorders mediated by interactions between chemokine receptors and their ligands.

Piperidine derivatives as CCR5 inhibitors

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Lörrach, Germany

Hans-Günter Zerwes