Abbott Gmbh & Co Kg

Basf Aktiengesellschaft

Gilead Colorado, Inc.

Hans-Guenther Hege

Helmut Lietz

Martina Ullrich

Andreas Kling

Andreas Haupt

Wilhelm Amberg

Thomas Zierke

Ernst Buschmann

Bernd Janssen

Kurt Ritter

Teresa Barlozzari

Harald Bernard

Gerda Von Philipsborn

Jurgen Weymann

Dieter Lenke

Manfred Raschack

Josef Gries

Albrecht Franke

Horst Koenig

Claus D Mueller

Lawrence S Melvin, Jr

Walter-Wielant Wiersdorff

Josef Mueller

Jürgen Weymann

Gerhard Eisen

Jurgen Weyman

The present invention provides antineoplastic peptides of formula I, wherein R, R, X, A, B, D, E, G, K and s have the meanings stated in the description. The compounds have antineoplastic activity.

Antineoplastic peptides

The invention relates to derivatives and metabolites of ambrisentan, including compounds of general Formula (I) or salts, hydrates, solvates, racemates, or optical isomers thereof, wherein Ris &#x2014;OH or &#x2014;OCH; Ris &#x2014;H, lower alkyl (e.g. C-Calkyl) or glycosidyl; and Rand Rare independently &#x2014;CH, &#x2014;C(O)H or &#x2014;CHOR, wherein Ris &#x2014;H or a hydrocarbyl group having 1 to 20 carbon atoms.

Metabolites and derivatives of ambrisentan

The present invention provides antineoplastic peptides of formula I,RRN&#x2014;CHX&#x2014;CO&#x2014;A&#x2014;B-D-E-(G)-Kwherein R, R, X, A, B, D, E, G, K and s have the meanings stated in the description. The compounds have antineoplastic activity.

The present invention provides antineoplastic peptides of formula I,RRN&#x2014;CHX&#x2014;CO-A-B-D-E-(G)-K Iwherein R, R, X, A, B, D, E, G, K, and s have the meanings stated in the description. The compounds have antineoplastic activity.

Pyridine derivatives of the formula ##STR1## where R.sup.1 to R.sup.4 have the meanings stated in the description, and their preparation. The substances are useful for treating disorders.

Compounds 1 or

Novel aminopropanol derivatives of 2-hydroxy-.beta.-phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.

Aminopropanol derivatives of 2-hydroxy-.beta.-phenyl-propiophenones,

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Neustadt, Germany

Hans-Guenther Hege