Merckle Gmbh

Hans-Guenter Striegel

Stefan Laufer

Karola Tollmann

Philipp Merckle

Susanne Tries

Wolfgang Albrecht

Thomas Kammermeier

Dunja Kotschenreuther

The invention relates to 2-thio-substituted imidazole derivatives of the formula I in which the radicals R, R, R, Rand p are as defined in the description. The compounds according to the invention have immunomodulating and/or cytokine-release-inhibiting action and are therefore suitable for treating disorders associated with a disturbed immune system.

2-thio-substituted imidazole derivatives and their use in pharmaceutics

The invention relates to 2-thio-substituted imidazole derivatives of the formula I in which the radicals R, R, Rand Rare as defined in the description. The compounds according to the invention have immunomodulating and/or cytokine-release-inhibiting action and are therefore suitable for treating disorders associated with a disturbed immune system.

2-thio-substituted imidazole derivatives and the use thereof in the pharmaceutical industry

The present invention relates to fused pyrrole compounds of the formula 1.in which at least one of the radicals R1, R2, R3 is 4-sulphur-substituted phenyl. These compounds are in particular pyrrolizines, indolizines and heteroanalogues having selective inhibitory action on isoenzyme-2 of prostaglandin H synthase (COX-2). The invention also relates to pharmaceutical compositions which contain these compounds; and the use of these compounds for the treatment of disorders of the rheumatic type.

Fused pyrrole compounds, pharmaceutical agents containing the same, and the use thereof

The present invention relates to compounds of the formula Iin which one of the radicals R8 and R9 is a hydrogen atom or an alkyl group and the other is hydroxyl, alkoxy or acyloxy or where R8 and R9, together with the carbon atom to which they are bonded, are a carbonyl group and the radicals R1 to R7 have the meanings indicated in the description. The compounds inhibit the release of various mediators of the arachidonic acid cascade and can thus be used for the prevention of allergically induced disorders or for the treatment of disorders of the rheumatic type.

Anti-inflammatory oxo derivatives and hydroxy derivatives of pyrrolizines, and their pharmaceutical use

The present invention relates to 4-pyridyl- and 2,4-pyrimidinyl-substituted pyrrole derivatives and their use in pharmacy, of the formula 1:in which the variables have the meanings indicated in the description. The compounds according to the invention have immunomodulating and/or cytokine release-inhibiting action and are therefore utilizable for the treatment of disorders which are connected with a disturbance of the immune system.

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Blaustein, Germany

Hans-Guenter Striegel