Johnson Matthey Public Limited Company

Lonza Inc.

Universita′ Degli Studi Di Udine

Hans Guenter Nedden

Antonio Zanotti-Gerosa

Alan Dyke

Stephen James Roseblade

Damian Mark Grainger

Sarah Facchetti

Jonathan Alan Medlock

Andreas Seger

Jacques Jean Marie Le Paih

Vilvanathan Sivakumar

Walter Baratta

Salvatore Baldino

Steven Giboulot

Markus Bicker

Miguel Angel Caraucán Dávila

Dario Veghini

Martin Wills

Golo Heckmann

Thomas Ward

Christophe Malan

Roy Hogkinson

Julien Pierron

Laleh Jafarpour

Vaclav Jurcik

Alan Malcolm Dyke

Zanotti-Gerosa Antonio

Jacques Jean-Marie Le Paih

Roy Hodgkinson

Miguel Angel CARAUCÁN DÁVILA

Disclosed are methods for the preparation of ligands for complexes, methods for preparing complexes and complexes having those ligands. Also provided is the use of a complex as a catalyst in a method of synthesis.

Complexes and methods for their preparation

The present invention relates to improved processes for the preparation of ruthenium or osmium complexes comprising P and N donor ligands, in particular, ruthenium complexes.

Processes for preparing phosphine diamine complexes of ruthenium and osmium

The present invention relates to improved processes for the preparation of ruthenium or osmium complexes comprising acetate ligands, in particular, ruthenium complexes.

Processes for preparing and using ruthenium and osmium complexes

The present invention relates to a process for hydrogenating a substrate including a carbon-heteroatom double bond, the process including the step of reacting the substrate with hydrogen gas in the presence of a hydrogenation catalyst, wherein the hydrogenation catalyst is a complex of formula (I): R, A and Hal are as defined in the specification. The present invention also provides processes for the preparation of the complex of formula (I) and intermediates thereof.

Process for hydrogenating ketones in the presence of Ru(II) catalysts

Process

An improved processes for the preparation of ruthenium or osmium complexes including P and N donor ligands, in particular, ruthenium complexes.

Processes for the preparation of ruthenium or osmium complexes comprising P and N donor ligands

A process for the synthesis of a cationic rhodium complex comprises the steps of: The complex may be recovered and used as a catalyst, for example in hydrogenation reactions.

Process for preparing cationic rhodium complexes

The present invention relates to a process for hydrogenating a substrate comprising a carbon-heteroatom double bond, the process comprising the step of reacting the substrate with hydrogen gas in the presence of a hydrogenation catalyst, wherein the hydrogenation catalyst is a complex of formula (I): R, A and Hal are as defined in the specification. The present invention also provides processes for the preparation of the complex of formula (I) and intermediates thereof. 

The present invention relates to the ruthenium complexes comprising paracyclophane and carbonyl ligands, methods for the preparation thereof and uses of the complexes in isomerization, hydrogenation, transfer hydrogenation, hydroformylation and carbonylation reactions.

Ruthenium complexes comprising paracyclophane and carbonyl ligands, and their use as catalyst

Ethereal solvents to precipitate [ruthenium (arene) (phosphorus ligand) (halogen)] complexes result in complexes having reduced stability. The stability of [ruthenium (arene) (phosphorus ligand) (halogen)] complexes is improved when the complexes are triturated or precipitated with at least one alkane. The at least one alkane can be pentane isomers, hexane isomers, heptane isomers, octane isomers and combinations thereof.

Process for preparing cationic ruthenium complexes

A process is described for the synthesis of a cationic [rhodium diolefin phosphorus ligand] complex comprising the steps of: (a) reacting a rhodium-diolefin-1,3-diketonate and an acid in a ketone solvent, (b) adding a stabilising olefin to form a stabilised cationic rhodium compound, and (c) mixing a phosphorus ligand with the solution of the stabilised cationic rhodium compound to form a solution of the cationic [rhodium diolefin phosphorus ligand] complex. The solution may be used directly or the complex recovered. In one embodiment, the solution may be combined with a co-solvent and the ketone removed to give a new catalyst solution, from which the complex may be recovered.

The invention relaters to a process for the production of an (S)- or (R)-4-halo-3-hydroxybutyrate, comprising reacting a 4-haloacetoacetate with hydrogen in the presence of a solvent, the solvent being a solvent mixture, which comprises a first solvent and a second solvent, wherein the first solvent is an aliphatic alcohol, preferably methanol, ethanol or propanol, and the second solvent is aprotic and comprises at least one oxygen atom; and

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Cambridgeshire, United Kingdom

Hans Guenter Nedden