C-a-i-r Biosciences Gmbh

Merckle Gmbh

Ratiopharm Gmbh

Hans-Günter Striegel

Stefan Laufer

Wolfgang Albrecht

Gerd Dannhardt

Karola Tollmann

Philipp Merckle

Thomas Kammermeier

Roland Boese

Nesrin Mohamad

Rüdiger Latz

Cornelia Greim

The present invention relates to the choline and tromethamine salt of Licofelone.

Choline and tromethamine salt of licofelone

The invention relates to 2-thio-substituted imidazole derivatives of the formula I in which the radicals R, R, Rand m are as defined in the description. The compounds according to the invention have immunomodulating and/or cytokine-release-inhibiting action and are therefore suitable for treating disorders associated with a disturbed immune system.

2-thio-substituted imidazole derivatives and their use in pharmaceutics

The invention relates to a process for the preparation of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-ylacetic acid, in which 5-benzyl-3,3-dimethyl-3,4-dihydro-2H-pyrrole is reacted with &#x3c9;-bromo-4-chloroacetophenone with formation of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizine and the acetic acid group is introduced into the 5-position, 5-benzyl-3,3-dimethyl-3,4-dihydro-2H-pyrrole being obtained by hydrogenation of 2,2-dimethyl-4-oxo-5-phenylvaleronitrile or a ketal thereof. The invention also relates to processes for the preparation of intermediates occurring in the above process.

Method for the production of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizin-5-ylacetic acid

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Blaustein, Germany

Hans-Günter Striegel