Agilent Technologies, Inc.

Hans-Georg Weissgerber

Alexander Bierbaum

Konstantin Choikhet

Hans-Peter Zimmermann

Martin Baeuerle

Bernd Glatz

Andreas Lorinser

A fluidic apparatus for a sample separation system includes a fluid inlet path for supplying a fluid, an inlet sensor adapted for measuring a flow rate of the fluid in the fluid inlet path, a splitting point arranged downstream of the fluid inlet path and adapted for splitting the fluid into a first path and into a second path, and a second path sensor adapted for measuring a flow rate of a part of the fluid conducted into the second path.

Apparatus for generating small flow rates in a channel

A method of determining a leak in a pumping system includes determining a metered flow rate of a fluid through a first channel, determining a measured flow rate within the channel, and identifying an amount of a leak in the pumping system as the difference between the metered flow rate and the measured flow rate.

Chromatography system with fluid intake management

A liquid chromatograph includes a mobile phase supplying apparatus including liquid-feeding pumps to feed mobile phases, liquid-feeding flow paths, a mixer to mix the mobile phases, at least one control device to control each liquid-feeding pump, flow rate measuring sections provided downstream in each liquid-feeding flow path configured to measure an actual flow rate and to detect a back-flow, and actual flow rate computing sections configured to compute an actual flow rate in the corresponding liquid feeding flow path. Also included are a sample injecting section downstream of the mobile phase supplying apparatus, a separating column for separating an injected sample into its constituents, and a detector for detecting each of the separated constituents. When one of the actual flow rate measuring sections detects a back-flow, the corresponding actual flow-rate computing section computes an actual back-flow rate and outputs a signal to the corresponding control device to cancel the back-flow.

A handling unit that comprises a first clamping element and a second clamping element, and an actuation mechanism adapted for driving at least one of the clamping elements. When the at least one of the clamping elements is driven to a first position, a microfluidic device may be placed between the clamping elements or taken out of the clamping elements, and when the at least one of the clamping elements is driven to a second position, the microfluidic device is gripped and fastened by the clamping elements.

Handling unit for microfluidic devices

A liquid delivery system having at least one channel, at least one valve within that channel, at least one flow sensing device within that channel, and a pressure source downstream of the valve capable for generating variable pressures.

Leakage checking and calibrating of a liquid delivery system

A variety of methods for operating a chromatography system are presented. Specifically, methods for operating a pumping system within a chromatography system are presented. The methods presented are directed to pumping apparatus in which very small amounts of fluid are pumped through the system. A number of techniques for detecting and compensating for leaks are presented as well as a number of techniques for operating the pumping system.

Chromatography system with waste output

Chromatography system with flow sensing

There is provided a method that includes, (a) monitoring a pressure on a fluid being conveyed through an intake tube into a chamber by a pump, (b) determining a deviation of the pressure from a predefined value, (c) determining a blockage of the intake tube based on the deviation, and (d) determining an amount of an adjustment of a parameter of the pump to compensate for the blockage.

Chromatography system with blockage determination

Method for the provision of fluid volume streams

Volume flows of liquids in capillary tubes of chromatographic separation columns for analytical liquid measuring technology are controlled. The volume flows are derived from a liquid transport, i.e., pump arrangement, which transports a total flow to a flow splitter that divides the total flow into an excess flow in an excess path and a working flow in a working path. A controller for the working flow responds to at least one working sensor. The working sensor senses the mass flow rate of the working flow and/or the pressure in the working path which is coupled with the working sensor or the pressure differential in conduits for the excess and working flows.

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Straubenhardt, Germany

Hans-Georg Weissgerber