Bayer Aktiengesellschaft

Wolff Walsrode Ag

Hans-Georg Rast

Heinz-Georg Wetzstein

Claus Weisemann

Wolfgang Kreiss

Thomas Himmler

Werner Hallenbach

Thomas Jaetsch

Martin Scheer

Dietmar Schapel

Werner Frommer

Michael Stegemann

Imre Pascik

Jorg Baumgarten

Franz Pirro

Ernst Heinen

Theo Mann

Stefan Bartel

Hans-Peter Stupp

Guenther Eberz

Uwe Priesnitz

Klaus Szablikowski

Ralf Dujardin

Ernst Grigat

Wolfgang Koch

Joachim Simon

Ralf Timmermann

Jurgen Engelhardt

Wolfgang Karl

Hanns Peter M&uuml;ller

G&uuml;nther Eberz

John Foster

Frank Berendes

Rainhardt Koch

Rainer Martens

Frantisek Zadrazil

Gunther Eberz

This application claims a method for detecting biologically active substances, comprising the following steps

Method and device for detecting biologically active substances

The invention claimed herein is a kit for detecting biologically active substances on a support, comprising the luminescent marine bacteriain a form stabilized for transport and storage, one or more cultivation media or the individual components of cultivation media for the microorganism wherein the cultivation media containsmg/l tomg/l of aspartic acid, and optionally additives for extending the period of luminescence selected from N-acylhomoserine lactones, dipeptides, oligopeptides, or their biochemical precursors, and boron compounds.

The present invention relates to novel optionally substituted 8-cyano-1-cyclo-propyl-7-(2,8-diazabicyclo&lsqb;4.3.0&rsqb;nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids and their derivatives, of the general formula (I)

Possibly substituted 8-cyano-1-cyclopropyl-7-(2,8-diazabicyclo-&lsqb;4.3.0&rsqb;-nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolin carboxylic acids and their derivatives

Intermediates useful in the preparation of 8-cyano-1-cyclopropyl-7-(2,8-diazabicyclo&lsqb;4.3.0&rsqb;nonan-8-yl-6-fluorol,4-dihydro-4-oxo-3-quinolinecarboxylic acids of the following structures are claimed.

Optionally substituted 8-cyano-1-cyclopropyl-7-(2,8-diazabicyclo&lsqb;4.3.0&rsqb;nonan-8-yl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids and their derivatives

The mixture to be tested for toxic components is first separated into fractions by chromatography. The separated fractions are then contacted with luminescent microorganisms in the chromatographic system itself and the toxicity of the fractions is determined by measurement of the bioluminescence. The chromatographic separation may be carried out either by thin layer chromatography or by column liquid chromatography.

Analytical process for testing mixtures for toxic constituents

The invention concerns novel plant-treatment agents comprising: at least one thermoplastically processable biodegradable polyester amide, optionally in a mixture with one or a plurality of further thermoplastically processable, biodegradable polymer components; at least one agrochemical substance; and optionally additives. The invention further concerns a process for preparing these agents, and their use in the application of agrochemical substances.

Plant-treatment agents

Method for producing cellulose derivatives

Methods for decomposing quinolones and naphthyridones

The method of producing luminescent bacteria is based on the transfer of genetic information for biological luminescence to obligate chemolithoautotrophic nitrifying microorganisms. In particular, luciferase DNA or a luciferase-beta-galactosidase transcription fusion is transferred into ammonia-oxidizing bacteria with the aid of plasmid- or transposon vector systems. The bioluminescent nitrification microorganisms, particularly Nitrosomonas strains modified by genetic engineering, are used in order to identify specific inhibitors during nitrification processes, the viability of these microorganisms being determined by measuring the decrease in luminescence. A particularly important application is that inhibitors in a nitrifying biological sewage treatment plant can be detected in this manner.

Luminescent nitrifying microorganisms

The object of the present invention is the production of thermoplastically workable copolymers capable of being composted, characterized in that they consist of partially crystalline soft segments formed from aliphatic esters and also of amorphous hard segments and that the proportion of soft segments amounts to 70% to 95% by weight.

Thermoplastic block copolyesters capable of being composted for use as

Waste water and/or outgoing air are purified by contact with a polyurethane hydrogel containing surface active coal, a polymer having cationic groups and cells having enzymatic activity and being capable of growth.

Biologically active composition for purifying waste water and outgoing

A biologically active composition is prepared comprising a polyurethane hydrogel containing surface active coal, a polymer having cationic groups and cells having enzymatic activity and being capable of growth. The composition is used for purifying waste water and outgoing air.

Immobilization of cells in polyurethane hydrogel

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Bergisch Gladbach, Germany

Hans-Georg Rast