Hoechst Aktiengesellschaft

Aventis Pharma Deutschland, Gmbh

Hans-Georg Alpermann

Hermann J Gerhards

Ulrich Stache

Manfred Bohn

Wolfgang Raether

Burkhard Sachse

Walter Dittmar

Klaus-Dieter Kampe

Herbert Siegel

Ulrich Schacht

Patricia Usinger

Margret Leven

Jochen Knolle

Klaus Wirth

Bernward Scholkens

Gerhard Breipohl

Stephan Henke

Walter D&uuml;rckheimer

Walter D Urckheimer

Corticoid 17,21-dicarboxylic esters and corticosteroid 17-carboxylic ester 21-carbonic esters, processes for their preparation and pharmaceuticals containing these compounds

17-Deoxycorticoid-21-carboxylic esters of the formula I ##STR1## are described, in which A is CHOH and CHCl, CH.sub.2, C.dbd.O or 9(11) double bond; Y is H, F or Cl; Z is H, F or CH.sub.3 ; R(1) is aryl or hetaryl and R(2) is H or methyl. They are obtained by reacting a compound of the formula II, ##STR2## in which R(4) is OH, with an activated carboxylic acid of the formula III,

17-deoxycorticosteroid-21-�O!carboxylic esters, processes for their

Corticoid 17-alkyl carbonate 21-carboxylic and carbonic esters of the formula I ##STR1## are described in which A is CHOH and CHCl, CH.sub.2, C.dbd.O or 9(11) double bond; Y is H, F or Cl; Z is H, F or CH.sub.3 ; R(1) is aryl or hetaryl; n and m are zero or 1; R(2) is alkyl or --(CH.sub.2).sub.2 --OCH.sub.3 ; R(3) is H or methyl. They are obtained by reacting a compound of the formula II, ##STR2## in which R(5) is OH, with an activated carboxylic acid of the formula III,

Corticosteroid 17-alkyl carbonate 21-[0]-carboxylic and carbonic esters,

Bradykinin peptides with modifications at the N terminus

Arylmethylazoles of the formula I ##STR1## in which Aryl is (substituted) phenyl or naphthyl;

Arylmethylazoles and their salts, agents which contain these compounds,

Arylmethylazole preparation processes

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Konigstein/Taunus, Germany

Hans-Georg Alpermann