Eastman-kodak Company

Rochester Institute of Technology

Carestream Health, Inc.

Bruker Biospin Gmbh

Hans F Schmitthenner

David T Southby

Donald R Diehl

John W Harder

Richard P Dunlap

David A Stegman

William J Harrison

Joan C Potenza

Ruizheng Wang

Marcel B Madaras

Robert J Niger

William J Sonnefeld

Tukaram K Hatwar

Margaret Jones Helber

Scott A Williams

Jeffrey W Leon

Manju Rajeswaran

Peter G Bessey

James R Bennett

Mihaela L Madaras

Brian J Kelley

Tao Ji

Chelsea Weidman

Stephanie Beach

Yonghong Yang

Anne M Sweeney-Jones

Taylor Barrett

A process for the preparation of a radionuclide imaging agent includes providing an imaging agent including a chelated place-holder metal; loading the imaging agent onto an acid stable stationary phase; replacing the chelated place-holder metal of the imaging agent loaded on the stationary phase with a replacement radioactive metal under mild reaction conditions; and eluting the imaging agent including the chelated replacement radioactive metal from the stationary phase to provide a radionuclide imaging agent suitable for positron emission tomography (PET) or single-photon emission computed tomography (SPECT). The imaging agent can include a targeting agent that is directly conjugated to the imaging agent or by means of a linker. The process may also apply to other metals that are non-radioactive but used as diluent metals or other metals that are strongly bound to DOTA.

Transmetalation methods for the synthesis of PET and SPECT imaging agents

Targeted molecular imaging agents (TMIAs) are derived from coupling together pre-formed amino acids with imaging agents attached to their side chains. These peptide-based imaging agents may synthesized from a single or multiple preformed amino acids containing multi-modal, multi-chelated metal, multi-dye imaging agents, or combinations of these, on the side chains of resultant peptides. These imaging amino acids or peptides may be conjugated directly, or activated, or attached to linkers to which targeting groups, such as peptides, proteins, antibodies, aptamers, or small molecule inhibitors, may be conjugated in the final steps of the synthesis to form a wide variety of TMIAs.

Modular imaging agents containing amino acids and peptides

The present invention relates to a loaded particle comprising at least one fluorescent dye, and in particular, a fluorescent dye with a large Stokes shift. The invention further relates to a method for producing an loaded latex particle, loaded with a fluorescent dye having a large stokes shift. In addition, the present invention relates to latex particles loaded with fluorescent dyes that are organic solvent soluble and insoluble in water. In a preferred embodiment, when the dyes are loaded into the water soluble latex particle, an increase is observed in quantum yield of fluorescence as compared to the quantum yield of the dye in aqueous solvent.

Loaded latex optical molecular imaging probes containing lipophilic large stokes shift dyes

The present invention relates to a diagnostic contrast agent comprising a water dispersible, near-infrared tricarbocyanine, enamine-functionalized dye having a Stoke shift of greater than 50 and represented by five general formulae. The present invention also relates to a method for making a dye-conjugate utilizing the novel dye and a method of identifying a biological compound using the novel dye conjugate.

Large stoke shift dye used for optical imaging

An electroluminescent device comprising a host material and a rubrene derivative having a naphthacene nucleus comprising four fused phenyl rings a, b, c, and d, in order, containing two secondary phenyl ring groups linked to the 'c' ring, each bearing directly or indirectly a fluoro or perfluoroalkyl group, wherein each fluoro or perfluoroalkyl group is either:

Organic element for electroluminescent devices

The invention relates to an ink composition comprising solubilized yellow dyes for inks with improved ozone and light stability.

Solubilized yellow dyes for inks with improved ozone and light stability

This invention relates to an ink composition comprising a dye represented by Formula I: wherein

Solubilized dyes for inks

Disclosed is a process for the preparation of a peptoid substituted azole compound comprising reacting an amino functionalized azole compound with a resin bound peptoid oligomer bearing a terminal halogen substituent followed by cleavage of the resultant product from the resin surface using a fluorinated organic acid in an inert solvent.

Synthesis of peptoid substituted azole compounds

Disclosed is a photographic element comprising a silver halide emulsion and a peptoid-containing azole dye-forming coupler.

Imaging materials containing peptoid substituted azole couplers

Growing community of inventors

Rush, NY, United States of America

Hans F Schmitthenner