Behringwerke Aktiengesellschaft

Dade Behring Marburg Gmbh

Hoechst Aktiengesellschaft

Siemens Healthcare Diagnostics Products Gmbh

Behring Diagnostics Gmbh

Hans-Erwin Pauly

Klaus Habenstein

Helmut Kohl

Stefan Brust

Wolfgang Kapmeyer

Heinz-Juergen Friesen

Ulrich Seitz

Guenther Nau

Carsten Schelp

Heinz-Jurgen Friesen

Joseph Stark

Gerd Grenner

Joseph St&auml;rk

Heinz-J&uuml;rgen Friesen

Joseph Stärk

Heinz-Jürgen Friesen

The invention relates to a method for quantitatively or qualitatively detecting an analyte in a sample, with the sample being incubated, for the purpose of avoiding, diminishing and/or detecting the high-dose hook effect, with an analyte-specific binding partner R1, which is associated with a solid phase, an analyte-specific binding partner R2, which is associated with a label L1, and an analyte-specific binding partner R3, which is associated with a label L2, and the L1-dependent measurement signal being determined either at a different time from the L2-dependent or L1 plus L2-dependent measurement signal or using a different measurement method.

Detection methods

A solid diagnostic device for the quantitative determination of substances of biological affinity in biological fluids is described. A process is also described in which the biological fluid is brought into contact with a specific functional sector of the device, the fluid migrates through several functional sectors situated beside one another and containing suitable reagent components, and one or more substances of biological affinity are detected in such functional sectors which contain, for each substance to be detected, at least one combination partner of biological affinity, attached to a solid phase.

Sheet-like diagnostic device

The invention relates to an artificial positive control reagents based on antibody conjugates that are used in immunochemical detection methods and to processes for the preparation of these reagents.

Artificial positive controls derived from bifunctional conjugates

The invention relates to artificial positive control reagents based on antibody conjugates that are used in immunochemical detection methods and to processes for the preparation of these reagents.

A biologically active latex conjugate prepared by the acidification of latex particles of a core/shell polymer having acetal groups in the shell, whereby said acetal groups are converted to aldehyde groups, and then bonding a biologically active substance having an amino group to said aldehyde groups by reductive amination.

Biologically active latex conjugate

What is disclosed is a latex, reactive with a biologically active substance to form a conjugate suitable for serological or immunological assay procedures, the particles of which latex comprises a polymer core and a shell thereover, said shell comprising a water insoluble monomer of the formula ##STR1## wherein R.sub.2 is H or CH.sub.3, n is 1 to 6, and R.sub.3 and R.sub.4 are alkyl, aryl, or same other group imparting water insolubility to said monomer.

Latex, biologically active latex conjugates and a process for their

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Dautphetal, Germany

Hans-Erwin Pauly